Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RGS16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RGS16 |
| Full Name | Regulator of G Protein Signaling 16 |
| Chromosome | 19q13.12 |
| Function | encodes a member of the RGS family of GTPase-activating proteins that negatively regulate G protein-coupled receptor signaling [1][2]. |
| Primary Expression | the suprachiasmatic nucleus, the master circadian clock of the hypothalamus [6] |
| Amino Acids | 120 aa |
| UniProt ID | O15410 |
| NCBI Gene ID | 6004 |
| Ensembl ID | ENSG00000128283 |
| OMIM | 602811 |
| GeneCards | RGS16 |
| Human Protein Atlas | RGS16 |
| RGS Domain | The conserved catalytic domain that mediates GAP activity toward Gα subunits |
| N-terminal Region | Contains a cysteine-rich sequence that may mediate palmitoylation and membrane association |
| PDZ-Binding Motif | C-terminal sequence that allows interaction with PDZ domain-containing proteins |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RGS16["RGS16"]
neurodegeneration["neurodegeneration"]
RGS16 -->|"implicated_in"| neurodegeneration
style RGS16 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RGS16 in their description or question text
No additional research found