Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RHOT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Mitochondrial Rho GTPase 2 (MIRO2) in Parkinson disease, mitophagy and mitochondrial dynamics
| Gene Symbol | RHOT2 |
| Full Name | Ras Homolog Family Member T2 |
| Aliases | MIRO2, Miro2, RhoT2 |
| Chromosome | 16p13.3. |
| Function | RHOT2 is a unique GTPase localized to the outer mitochondrial membrane that serves as a molecular hub connecting mitochondrial dynamics with cellular signaling. |
| Primary Expression | High in brain (substantia nigra), heart, skeletal muscle |
| Subcellular Localization | the outer mitochondrial membrane that serves as a molecular hub connecting mitochondrial dynamics with cellular signalin |
| Molecular Weight | ~71 kDa |
| Amino Acids | 618 aa |
| UniProt ID | Q8IXI2 |
| NCBI Gene ID | 55103 |
| Ensembl ID | ENSG00000150990 |
| OMIM | 612606 |
| GeneCards | RHOT2 |
| Human Protein Atlas | RHOT2 |
| Associated Diseases | neurodegeneration |
| Interactions | MIRO1 |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RHOT2["RHOT2"]
style RHOT2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
microglia["microglia"]
MIRO1(["MIRO1"])
neurodegeneration["neurodegeneration"]
RHOT2 -->|"expressed_in"| microglia
MIRO1 -->|"activates"| RHOT2
RHOT2 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class microglia mechanism
class MIRO1 protein
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| microglia | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MIRO1 | activates | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity