protein

MIRO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MIRO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1116Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Miro1 (RHOT1) is a mitochondrial Rho GTPase that regulates mitochondrial transport, calcium homeostasis, and quality control in neurons, with critical roles in Alzheimer's disease, Parkinson's disease, and ALS pathogenesis

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🔬 Protein Info

Gene Symbol	MIRO1
Aliases	RHOT1
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	MIRO1-targeting drugs modulate GTPase activity to enhance mitochondrial transport along axons and improve mitochondrial quality control through selective autophagy. By regulating MIRO1's interactio...
Mechanism of Action	MIRO1-targeting drugs modulate GTPase activity to enhance mitochondrial transport along axons and improve mitochondrial quality control through selective autophagy. By regulating MIRO1's interaction with kinesin motor proteins and PINK1-mediated mitophagy, these compounds restore energy homeostasis and reduce neuronal stress in neurodegenerative diseases.
Druggability	Low (0.29)
Clinical Stage	Phase II
Molecular Weight	71 kDa
Pathways	Mitochondrial Function, Mitochondrial dynamics / bioenergetics, Therapeutic Target Development
UniProt ID	Q8IXI2
GeneCards	MIRO1
Human Protein Atlas	MIRO1
Associated Diseases	AD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compounds	Miro-inhibitor-001, GTPASE-mod-42, Mitochondrial transport enhancer XR-789, MIRO1-stabilizing compound MRS-2
Interactions	CTSD, RB1, EIF2AK3, PRKN, BCL2L11, MUL1
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Mitochondrial Transfer Pathway Enhancement
KG Connections	1099 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MIRO1 — AlphaFold Q8IXI2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MIRO1["MIRO1"] -->|"interacts with"| Dementia["Dementia"]
    MIRO1["MIRO1"] -->|"interacts with"| Cardiovascular["Cardiovascular"]
    MIRO1["MIRO1"] -->|"interacts with"| Als["Als"]
    MIRO1["MIRO1"] -->|"interacts with"| Alzheimer["Alzheimer"]
    MIRO1["MIRO1"] -->|"interacts with"| Parkinson["Parkinson"]
    MIRO1["MIRO1"] -->|"interacts with"| Ms["Ms"]
    h_969bd8e0["h-969bd8e0"] -->|"targets"| MIRO1["MIRO1"]
    CAT["CAT"] -->|"interacts with"| MIRO1["MIRO1"]
    OPTN["OPTN"] -->|"interacts with"| MIRO1["MIRO1"]
    DNM1L["DNM1L"] -->|"interacts with"| MIRO1["MIRO1"]
    style MIRO1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (659)

Target	Relation	Type	Str
ALS	downregulated_in	disease	1.00
Neurological Disorders	targets	disease	0.95
Mitochondrial-Derived Vesicle Biogenesis	activates	process	0.95
Intercellular Mitochondrial Transport	regulates	process	0.95
Mitochondrial Transfer	regulates	process	0.95
Mitochondrial Transport	regulates	pathway	0.95
Mitochondrial Transfer	involved_in	process	0.95
Mitochondrial-Derived Vesicle Biogenesis	promotes	process	0.95
Mitochondrial Transport	involved_in	process	0.95
mitochondrial transfer	mediates	process	0.95
mitochondrial-derived vesicle biogenesis	drives	process	0.95
Cerebral Ischemia-Reperfusion Injury	protects_against	disease	0.95
MITOCHONDRIAL TRANSFER	regulates	entity	0.95
MESENCHYMAL STEM CELL	expressed_in	entity	0.90
EPITHELIAL CELL INJURY	protects_against	entity	0.90
Neurological Disorders	associated_with	disease	0.90
Therapeutic Target Development	involved_in	process	0.90
Mesenchymal Stem Cell	expressed_in	cell_type	0.90
Neurological Disorders	therapeutic_target	disease	0.90
Mitochondrial Rho Gtpase	encodes	protein	0.90
Mitochondrial Motility	mediates	process	0.90
Calcium Sequestration	involved_in	process	0.90
Mitochondrial motility	regulates	process	0.90
membrane protrusion formation	mediates	process	0.90
epithelial cell mitochondrial dysfunction	regulates	phenotype	0.90
epithelial injury rescue	promotes	process	0.90
TRAK1	binds	protein	0.90
MITOCHONDRIAL QUALITY CONTROL	involved_in	entity	0.90
OSTEOCLAST	regulates	entity	0.90
ASTROCYTES	expressed_in	cell_type	0.90
Parkinson'S Disease	associated_with	disease	0.90
mitochondrial function	modulates	process	0.90
Microtubule Filaments	interacts_with	entity	0.85
AIRWAY HYPERRESPONSIVENESS	protects_against	entity	0.85
MIRO2	interacts_with	entity	0.85
Epithelial Cell Injury	inhibits	process	0.85
Mitochondrial Dynamics	regulates	process	0.85
Energy Production	regulates	process	0.85
Parkinson disease	associated_with	disease	0.85
bone resorption	suppresses	process	0.85
neuronal viability	promotes	phenotype	0.85
asthma	therapeutic_target	disease	0.85
airway hyperresponsiveness	suppresses	phenotype	0.85
airway remodeling	suppresses	phenotype	0.85
mitochondrial transfer	associated_with	process	0.85
Mitochondrial Transfer	mediates	mechanism	0.85
FERROPTOSIS	involved_in	entity	0.85
MITOCHONDRIAL DYSFUNCTION	protects_against	entity	0.85
Mitochondrial Function	involved_in	process	0.85
Neurodegeneration	contributes_to	phenotype	0.85

Incoming (457)

Source	Relation	Type	Str
SNCA	upregulates	protein	0.95
RHOT1	encodes	gene	0.95
GJ-PD	upregulates	drug	0.90
h-969bd8e0	targets_gene	hypothesis	0.90
h-969bd8e0	targets	hypothesis	0.80
PARKIN	ubiquitinates	gene	0.80
PRKN	targets	protein	0.80
GJ-PD herbal pair	upregulates	drug	0.80
electroacupuncture	upregulates	drug	0.80
Geum japonicum Thunb. var. chinense-Potentilla decorata H. Andres	upregulates	drug	0.80
PINK1	phosphorylates	protein	0.75
CD38	interacts_with	gene	0.75
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
JUN	activates	gene	0.60
DRP1	interacts_with	gene	0.60
TOMM20	regulates	gene	0.60
MAX	regulates	gene	0.60
JUN	regulates	gene	0.60
BAX	activates	gene	0.60
APP	expressed_in	gene	0.60
SNPH	expressed_in	gene	0.60
PARKIN	activates	gene	0.60
PINK1	activates	gene	0.60
PTEN	activates	gene	0.60
MIRO2	associated_with	gene	0.60
GBA	associated_with	gene	0.60
SNCA	associated_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mitochondrial Transfer Pathway Enhancement	0.443	neurodegeneration	Astrocyte reactivity subtypes in neurode
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy	0.426	neurodegeneration	Mitochondrial transfer between neurons a

Mentioning Analyses (1)

Scientific analyses that reference this entity

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.554

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886]	Yao RQ, Ren C, Xia ZF, Yao YM	Autophagy	2021	2
Miro1: A potential target for treating neurological disorders. [PMID:40403957]	Zeng L, Yang J, Zhang C, Zhu J, Zhong S,	Neuroscience	2025	1
Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorpt [PMID:38877020]	Ding P, Gao C, Zhou J, Mei J, Li G, Liu	Nat Commun	2024	1
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote qualit [PMID:34873283]	König T, Nolte H, Aaltonen MJ, Tatsuta T	Nat Cell Biol	2021	1
Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal ste [PMID:24431222]	Ahmad T, Mukherjee S, Pattnaik B, Kumar	EMBO J	2014	1
Dihuang Yinzi ameliorates post-stroke depression through Miro1 ubiquitination-de [PMID:41850637]	Chang H, Ji Z, Sun Q, Zhou S, Yang Z, Qu	Journal of ethnopharmacology	2026	0
L-Carnitine and Acetyl-L-Carnitine in Drug Poisonings: A Systematic Review of Cl [PMID:41692009]	["Rezaee H", "Abbasgholizadeh F"]	Journal of applied toxicology	2026	0
Mechanistic Insights into the Cardioprotective Effects of Mesenchymal Stem Cell- [PMID:41900832]	["Othman Basri N", "Che Roos N", "Aminud	Pharmaceutics	2026	0
Miro1 in Parkinson's Disease: A Key Regulator of Mitochondrial Homeostasis and N [PMID:41792389]	Singh G, Kaur S, Aran KR	Neuromolecular medicine	2026	0
Boronophenylalanine-Mediated Boron Neutron Capture Therapy Confers Selective Kil [PMID:41817167]	["Zhang L", "Quan R", "Huang H", "Wu M",	Cancer biotherapy & radiopharm	2026	0
Miro1 Mediates the Neuroprotective Effects of Electroacupuncture Against Cerebra [PMID:41914243]	["Lian H", "Sun Y", "Zhang M", "Gao X",	Journal of integrative neurosc	2026	0
Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates C [PMID:41678910]	["Sun F", "She R", "Yang T", "Chen B", "	Phytomedicine : international	2026	0
Miro1 protects against brain injury after CPR in rats by enhancing the effect of [PMID:41153049]	Ma X, Shen M, Hu J, Zhu J, Wang Z, Zhou	Stem cell research & therapy	2025	0
Parkinson's disease mutant Miro1 causes mitochondrial dysfunction and dopaminerg [PMID:39913247]	Chemla A, Arena G, Sacripanti G, Barmpa	Brain : a journal of neurology	2025	0
Selenium nanoparticles activate selenoproteins to mitigate septic lung injury th [PMID:40114196]	["Gu W", "Zhao F", "Huang W", "Zhu M", "	Journal of nanobiotechnology	2025	0
Targeting Mitochondrial Dynamics via EV Delivery in Regenerative Cardiology: Mec [PMID:41227383]	["Shahannaz D", "Sugiura T", "Ferrell B"	Cells	2025	0
Super mitochondria-enriched extracellular vesicles enable enhanced mitochondria [PMID:41145425]	["Wang Y", "Yu H", "Yi Z", "Qi L", "Yang	Nature communications	2025	0
Dimethyl fumarate reprograms cervical cancer cells to enhance antitumor immunity [PMID:41116174]	["Jiang H", "Liu L", "He S", "Qu S", "Ya	Journal of biomedical science	2025	0
Mechanisms of electroacupuncture-induced neuroprotection in acute stroke rats: t [PMID:40598228]	["Guo Y", "Fu T", "Cheng Y", "Li Y", "Zh	Cell communication and signali	2025	0
The tumour microenvironment, treatment resistance and recurrence in glioblastoma [PMID:38844944]	["White J", "White M", "Wickremesekera A	Journal of translational medic	2024	0

MIRO1

Understanding Entity Pages

Summary

Wiki Pages (20)

Novel Therapy Index

Therapeutics

Mitochondrial Dysfunction in Parkinson's Disease

Mitophagy Pathway in Neurodegeneration

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

Synaptic Vesicle Trafficking in Parkinson's Disease

Mitochondria in Neurodegeneration

Tunneling Nanotubes in Neurodegeneration

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

mitochondrial-dynamics

Calcium Dysregulation in Neurodegenerative Diseases

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

Exercise-BDNF-Mitochondrial Resilience Hypothesis

PINK1-Parkin Mitophagy Pathway in Parkinson's Disease

Axonal Transport Rescue Therapy for Neurodegeneration

Mitochondria-Lysosome Contact Sites (MLCS) in Neurodegeneration

MYO10 and Mitochondrial Transfer in Neurodegeneration

KIF28P — Kinesin Family Member 28, Pseudogene

Ferroptosis