protein

RIMS2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RIMS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for RIMS2 Protein

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🔬 Protein Info

Gene Symbol	RIMS2
Protein Type	Gene
Function	RIMS2 (Regulating Synaptic Membrane Exocytosis 2), also known as RIM2, is a critical presynaptic protein that regulates synaptic vesicle docking, priming, and fusion.
Amino Acids	777 aa
UniProt ID	Q9UQ26
Ensembl ID	ENSG00000155380
GeneCards	RIMS2
Human Protein Atlas	RIMS2
Synaptic vesicle priming	RIMS2 helps vesicles reach a fusion-ready state
Calcium channel coupling	RIMS2 links voltage-gated calcium channels to vesicle release sites
Active zone organization	RIMS2 is a core component of the active zone cytomatrix
Synaptic vesicle recycling	Regulates endocytosis and vesicle replenishment
RAB3A/B	Small GTPases that regulate vesicle trafficking
MUNC13	Vesicle priming proteins
CAPS	Vesicle priming factors
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: RIMS2 — AlphaFold Q9UQ26 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RIMS2 Gene

gene · 615 words

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RIMS2 Protein

protein · 784 words

→

Pathway Diagram

graph TD
    RIMS2["RIMS2"]
    neurodegeneration["neurodegeneration"]
    RIMS2 -->|"implicated_in"| neurodegeneration
    style RIMS2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RIMS2 in their description or question text

No additional research found