entity

RNA-

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNA-: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

30Hypotheses

7Analyses

0Outgoing

0Incoming

1Experiments

8Debates

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Wiki Pages (11)

Knowledge base pages for this entity

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated	0.865	molecular neurobiology	View
TDP-43 RNA-proteostasis failure across ALS, FTD, and AD/LATE	0.828	multi	Cross-disease neurodegeneration mechanis
Stress-granule RNA-binding protein phase transition across A	0.780	multi	Cross-disease neurodegeneration mechanis
METTL3-Mediated m6A Modification of lncRNA-0021 Regulates mi	0.759	molecular neurobiology	View
Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-002	0.733	molecular neurobiology	View

hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-002	0.684	molecular neurobiology	View
Seed match plus local RNA structure jointly determine lncRNA	0.670	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
RNA-binding protein condensate maturation from reversible ph	0.626	neurodegeneration	Causal Sequence of TDP-43 Nuclear Cleara
RNA-binding protein condensate maturation from reversible ph	0.626	neurodegeneration	Biophysical Determinants Shifting FUS/TD
APOE ε4-driven microglial lipid handling as proximal driver	0.626	neurodegeneration	Non-Neuronal Transcriptional Changes Pre
Integrated Blood Panel of sPDGFRβ, sTM, and Circulating micr	0.625	-	What blood-brain barrier permeability ch
RNA-Binding Protein Sequestration and 3′UTR Dysregulation	0.625	-	How does the intron-retained RNA isoform
A pre-organized hairpin or loop in lncRNA-0021 creates a hig	0.550	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
Cerebrospinal Fluid p-tau217-Guided Astrocyte-Derived Extrac	0.542	molecular neurobiology	View
Cerebrospinal NFL-Triggered Liposome Dosing Maximizes lncRNA	0.517	molecular neurobiology	View
RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-m	0.497	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding	0.465	neurodegeneration	Protein aggregation cross-seeding across
Alpha-Beta Oscillation Coupling Enhances lncRNA-9969-Mediate	0.460	molecular neurobiology	View
CSF Neurofilament Light Chain-Guided Astrocyte-Derived Extra	0.458	molecular neurobiology	View
CSF Neurofilament Light-Triggered Astrocyte-Derived Exosome	0.450	molecular neurobiology	View
Alpha-Beta Oscillation Entrainment Enhances lncRNA-9969-Medi	0.434	molecular neurobiology	View
Gamma-Entrained P-tau217 Biomarker Cascades Optimize lncRNA-	0.431	molecular neurobiology	View
Theta-Gamma Coupling Modulates lncRNA-9969-Mediated Mitochon	0.424	molecular neurobiology	View
Alpha-Theta Oscillation Modulation Enhances lncRNA-9969-Medi	0.421	molecular neurobiology	View
Dicer-Processed siRNA-Mediated Transcript Silencing	0.405	-	How does the intron-retained RNA isoform
LncRNA-HDAC1 Complex Formation Locks Microglia in Primed Sta	0.400	developmental neurobiology	Do perinatal immune challenges create pe
A-to-I RNA editing modulates the lncRNA-0021 binding site an	0.387	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
CREB1-Induced lncRNA-9969 Selectively Sequesters miR-6361 Th	0.380	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
CREB1-Induced lncRNA-9969 Selectively Binds miR-6361 Through	0.380	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
Theta-Alpha Oscillation Entrainment Enhances lncRNA-9969-Med	0.380	molecular neurobiology	View

Mentioning Analyses (7)

Scientific analyses that reference this entity

Non-Neuronal Transcriptional Changes Preceding Tau Propagation as Early AD Bioma

neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.626

Microglial Priming as Upstream Causal Node Across AD, PD, ALS, MS: Three-Arm Cau

neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.604

Which specific factors in conditioned medium from healthy astrocytes rescue moto

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.730

How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what

molecular neurobiology | 2026-04-25 | 9 hypotheses Top: 0.670

scRNA-seq Processing and Cell Type Annotation of AD Brain

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.582

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells under arsenite	proposed	N/A

Related Papers (10)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Roles of NAD+ in Health and Aging. [PMID:37848251]	Lautrup S, Hou Y, Fang EF, Bohr VA	Cold Spring Harbor perspective	2024
The different autophagy degradation pathways and neurodegeneration. [PMID:35134347]	Fleming A, Bourdenx M, Fujimaki M, Karab	Neuron	2022
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559]	["Wan Huida", "Wang Qi", "Chen Xiuting",	Autophagy	2020
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559]	["Wan Huida", "Wang Qi", "Chen Xiuting",	Autophagy	2020
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive defi [PMID:30742114]	Unknown	Nature neuroscience	2019
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Prom [PMID:28817800]	["Mackenzie Ian R", "Nicholson Alexandra	Neuron	2017
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem prote [PMID:23455423]	Unknown	Nature	2013
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-lin [PMID:21944779]	Unknown	Neuron	2011
TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. [PMID:17469117]	Unknown	Annals of neurology	2007
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic latera [PMID:17023659]	Unknown	Science (New York, N.Y.)	2006

Debates (8)

Multi-agent debates referencing this entity

Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream

active · Rounds: 4 · Score: 0.64 · 2026-04-28

Which non-neuronal cell types (astrocytes, oligodendrocytes, pericytes) exhibit

active · Rounds: 4 · Score: 0.67 · 2026-04-28

Which specific factors in conditioned medium from healthy astrocytes rescue moto

closed · Rounds: 4 · Score: 0.65 · 2026-04-25

How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what

closed · Rounds: 4 · Score: 0.66 · 2026-04-25

Can standardized scRNA-seq processing and automated annotation identify novel ce

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Does the hybrid DAM + interferon-response microglial population represent a nove

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

The abstract shows that dilncRNAs drive molecular crowding of DDR proteins into

closed · Rounds: 7 · Score: 0.90 · 2026-04-10

While the study shows 53BP1 forms phase-separated foci driven by dilncRNAs, it's

closed · Rounds: 7 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning RNA- in their description or question text

hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-0021 Accessibility for

Score: 0.684 · molecular neurobiology · 2026-04-17

## **Molecular Mechanism and Rationale** The proposed therapeutic mechanism centers on the regulatory interplay between

Seed match plus local RNA structure jointly determine lncRNA-0021 binding to mmu

Score: 0.670 · molecular neurobiology · 2026-04-25

The most likely explanation is a two-factor recognition mechanism: a canonical miRNA seed-complementary site in lncRNA-0

RNA-binding protein condensate maturation from reversible phase separation to am

Score: 0.626 · neurodegeneration · 2026-04-28

RNA-binding protein condensate maturation from reversible phase separation to amyloid-like aggregation should produce a

RNA-binding protein condensate maturation from reversible phase separation to am

Score: 0.626 · neurodegeneration · 2026-04-28

RNA-binding protein condensate maturation from reversible phase separation to amyloid-like aggregation should produce a

APOE ε4-driven microglial lipid handling as proximal driver in Non-Neuronal Tran

Score: 0.626 · neurodegeneration · 2026-04-28

APOE ε4-driven microglial lipid handling should produce a measurable proximal phenotype before late disease pathology. T

Integrated Blood Panel of sPDGFRβ, sTM, and Circulating microRNA-320 Predicts Pr

Score: 0.625 · unknown disease · 2026-04-26

No single biomarker fully captures the heterogeneity of early BBB dysfunction across neurodegeneration subtypes. A compo

RNA-Binding Protein Sequestration and 3′UTR Dysregulation

Score: 0.625 · unknown disease · 2026-04-26

Intron-retained GBA isoform sequesters neuronal RBPs (FMRP, HuR, TDP-43) that normally bind to wild-type GBA mRNA 3′UTR

A pre-organized hairpin or loop in lncRNA-0021 creates a high-affinity docking s

Score: 0.550 · molecular neurobiology · 2026-04-25

lncRNA-0021 may contain a pre-folded structural element that lowers the entropic cost of binding and presents the miR-63

Cerebrospinal Fluid p-tau217-Guided Astrocyte-Derived Extracellular Vesicle Deli

Score: 0.542 · molecular neurobiology · 2026-04-17

## Mechanistic Overview Cerebrospinal Fluid p-tau217-Guided Astrocyte-Derived Extracellular Vesicle Delivery of lncRNA-0

Cerebrospinal NFL-Triggered Liposome Dosing Maximizes lncRNA-0021 Therapeutic Wi

Score: 0.517 · molecular neurobiology · 2026-04-20

## Mechanistic Overview Cerebrospinal NFL-Triggered Liposome Dosing Maximizes lncRNA-0021 Therapeutic Window in AD start

RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-miR-6361 duplex

Score: 0.497 · molecular neurobiology · 2026-04-25

An auxiliary protein, such as TDP-43, FUS, or an hnRNP family member, may bind lncRNA-0021 and/or mmu-miR-6361 to increa

RNA-Binding Competition Therapy for TDP-43 Cross-Seeding

Score: 0.465 · neurodegeneration · 2026-04-02

Synthetic RNA aptamers designed to competitively bind TDP-43's RNA recognition motifs could prevent its interaction with

Alpha-Beta Oscillation Coupling Enhances lncRNA-9969-Mediated Autophagy Through

Score: 0.460 · molecular neurobiology · 2026-04-21

## Mechanistic Overview Alpha-Beta Oscillation Coupling Enhances lncRNA-9969-Mediated Autophagy Through SST Interneuron-

CSF Neurofilament Light Chain-Guided Astrocyte-Derived Extracellular Vesicle Del

Score: 0.458 · molecular neurobiology · 2026-04-21

## Mechanistic Overview CSF Neurofilament Light Chain-Guided Astrocyte-Derived Extracellular Vesicle Delivery of lncRNA-

CSF Neurofilament Light-Triggered Astrocyte-Derived Exosome Dosing Maximizes lnc

Score: 0.450 · molecular neurobiology · 2026-04-21

## Mechanistic Overview CSF Neurofilament Light-Triggered Astrocyte-Derived Exosome Dosing Maximizes lncRNA-0021 Therape

RNA-

Understanding Entity Pages

Wiki Pages (11)

RNA-Targeted Therapies in Neurodegeneration

IGF2BP3 — Insulin-Like Growth Factor 2 mRNA-Binding Protein 3

mRNA-Encoded Intrabody for Alpha-Synuclein Clearance

C9orf72 RNA-Targeting Dipeptide Repeat Reduction

AD RNA-Based Therapeutics Companies

RNA-Targeted Therapeutics Investment Synthesis

RNA-Based Therapeutics for Alzheimer's Disease

RNA-Targeting Therapies for Neurodegenerative Diseases

MicroRNA-Based Therapies for Neurodegeneration

RNA-Based Therapeutics for Neurodegenerative Diseases

Single Nucleus RNA Sequencing (snRNA-seq)

Outgoing (0)

Incoming (0)

Targeting Hypotheses (30)

Mentioning Analyses (7)

Non-Neuronal Transcriptional Changes Preceding Tau Propagation as Early AD Bioma

Microglial Priming as Upstream Causal Node Across AD, PD, ALS, MS: Three-Arm Cau

Which specific factors in conditioned medium from healthy astrocytes rescue moto

How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what

scRNA-seq Processing and Cell Type Annotation of AD Brain

What determines the specificity of DDR protein recruitment to dilncRNA-induced c

How do dilncRNAs specifically drive molecular crowding and phase separation of D

Experiments (1)

Related Papers (10)

Debates (8)

Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream

Which non-neuronal cell types (astrocytes, oligodendrocytes, pericytes) exhibit

Which specific factors in conditioned medium from healthy astrocytes rescue moto

How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what

Can standardized scRNA-seq processing and automated annotation identify novel ce

Does the hybrid DAM + interferon-response microglial population represent a nove

The abstract shows that dilncRNAs drive molecular crowding of DDR proteins into

While the study shows 53BP1 forms phase-separated foci driven by dilncRNAs, it's

Related Research

hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-0021 Accessibility for

Seed match plus local RNA structure jointly determine lncRNA-0021 binding to mmu

RNA-binding protein condensate maturation from reversible phase separation to am

RNA-binding protein condensate maturation from reversible phase separation to am

APOE ε4-driven microglial lipid handling as proximal driver in Non-Neuronal Tran

Integrated Blood Panel of sPDGFRβ, sTM, and Circulating microRNA-320 Predicts Pr

RNA-Binding Protein Sequestration and 3′UTR Dysregulation

A pre-organized hairpin or loop in lncRNA-0021 creates a high-affinity docking s

Cerebrospinal Fluid p-tau217-Guided Astrocyte-Derived Extracellular Vesicle Deli

Cerebrospinal NFL-Triggered Liposome Dosing Maximizes lncRNA-0021 Therapeutic Wi

RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-miR-6361 duplex

RNA-Binding Competition Therapy for TDP-43 Cross-Seeding

Alpha-Beta Oscillation Coupling Enhances lncRNA-9969-Mediated Autophagy Through

CSF Neurofilament Light Chain-Guided Astrocyte-Derived Extracellular Vesicle Del

CSF Neurofilament Light-Triggered Astrocyte-Derived Exosome Dosing Maximizes lnc