Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RNF186: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RNF186 |
| Full Name | Ring Finger Protein 186 |
| Chromosome | 9q32 |
| Protein Type | Ligase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | neuronal tissues where it participates in protein quality control, ER-associated degradation (ERAD), and cellular stress responses |
| Subcellular Localization | - **N-terminal signal peptide**: Targeting to secretory pathway ## Molecular Fu |
| UniProt ID | Q96MC7 |
| GeneCards | RNF186 |
| Human Protein Atlas | RNF186 |
| Misfolded membrane proteins | General substrate for ER quality control |
| Inflammatory signaling proteins | Potential regulation of NF-κB and other pathways |
| Gut-brain axis proteins | Connections to enteric nervous system function |
| Gastrointestinal tract | Highest expression in intestinal epithelium, particularly colon |
| Brain | Moderate expression in cortex, hippocampus, and cerebellum |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RNF186["RNF186"]
neurodegeneration["neurodegeneration"]
RNF186 -->|"implicated_in"| neurodegeneration
style RNF186 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RNF186 in their description or question text
No additional research found