| Gene Symbol | RNF186 |
| Full Name | Ring Finger Protein 186 |
| Chromosome | 9q32 |
| Protein Type | Ligase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | neuronal tissues where it participates in protein quality control, ER-associated degradation (ERAD), and cellular stress responses |
| Subcellular Localization | - **N-terminal signal peptide**: Targeting to secretory pathway ## Molecular Fu |
| UniProt ID | Q96MC7 |
| GeneCards | RNF186 |
| Human Protein Atlas | RNF186 |
| Misfolded membrane proteins | General substrate for ER quality control |
| Inflammatory signaling proteins | Potential regulation of NF-κB and other pathways |
| Gut-brain axis proteins | Connections to enteric nervous system function |
| Gastrointestinal tract | Highest expression in intestinal epithelium, particularly colon |
| Brain | Moderate expression in cortex, hippocampus, and cerebellum |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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