gene

RPL18A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPL18A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

3Outgoing

0Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	RPL18A
Function	encodes a ribosomal protein component of the 60S large ribosomal subunit.
Molecular Weight	20 kDa
Amino Acids	176 aa
Ensembl ID	ENSG00000105640
GeneCards	RPL18A
Human Protein Atlas	RPL18A
Protein synthesis	Contributes to peptide bond formation at the peptidyl transferase center
Ribosome assembly	Essential for proper 60S subunit biogenesis
rRNA interaction	Interacts with 28S rRNA to stabilize the large subunit
Translation termination	Participates in the release factor binding site
Subunit association	Critical for proper 60S assembly and 80S ribosome formation
N-terminal domain	Contains RNA-binding regions
Central region	Involved in protein-protein interactions with other ribosomal proteins
Surface localization	Positioned to interact with both ribosomal components and extraribosomal factors
Associated Diseases	Aortic Valve Calcification, Salivary Gland Damage
KG Connections	3 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RPL18A Gene - Ribosomal Protein L18a

gene · 1245 words

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Genes

index · 271 words

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Pathway Diagram

graph TD
    RPL18A["RPL18A"]
    Melatonin["Melatonin"]
    Salivary_Gland_Damage["Salivary Gland Damage"]
    Aortic_Valve_Calcification["Aortic Valve Calcification"]
    neurodegeneration["neurodegeneration"]

    RPL18A -->|"regulates"| Melatonin
    RPL18A -->|"associated with"| Salivary_Gland_Damage
    RPL18A -->|"associated with"| Aortic_Valve_Calcification
    RPL18A -->|"implicated in"| neurodegeneration

    style RPL18A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Melatonin fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff
    style Salivary_Gland_Damage fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff
    style Aortic_Valve_Calcification fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff

Outgoing (3)

Target	Relation	Type	Str
Melatonin	regulates	chemical	0.70
Salivary Gland Damage	associated_with	phenotype	0.60
Aortic Valve Calcification	associated_with	disease	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found