Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Melatonin: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Melatonin |
| Key Genes/Proteins | SIRT1, MMP2, NR3C1 |
| Related Diseases | Alzheimer's Disease, Alzheimer'S Disease, Polycystic Ovary Syndrome |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
Melatonin["Melatonin"] -->|"treats"| Sepsis_Induced_Acute_Kidney_In["Sepsis-Induced Acute Kidney Injury"]
style Sepsis_Induced_Acute_Kidney_In fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Melatonin["Melatonin"] -->|"regulates"| SOX2["SOX2"]
style SOX2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Melatonin["Melatonin"] -->|"regulates"| OCT4["OCT4"]
style OCT4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Melatonin["Melatonin"] -->|"regulates"| NANOG["NANOG"]
style NANOG fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Melatonin["Melatonin"] -->|"regulates"| POU5F1["POU5F1"]
style POU5F1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Melatonin["Melatonin"] -->|"treats"| Diabetic_Cardiomyopathy["Diabetic Cardiomyopathy"]
style Diabetic_Cardiomyopathy fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Melatonin["Melatonin"] -->|"treats"| Alzheimer_s_Disease["Alzheimer's Disease"]
style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Circadian_Clock_Genes["Circadian Clock Genes"] -->|"regulates"| Melatonin["Melatonin"]
style Circadian_Clock_Genes fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
OSAS["OSAS"] -->|"associated"| Melatonin["Melatonin"]
style OSAS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Circadian["Circadian"] -->|"interacts"| Melatonin["Melatonin"]
style Circadian fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
RPL18A["RPL18A"] -->|"regulates"| Melatonin["Melatonin"]
style RPL18A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
MMP2["MMP2"] -->|"involved in"| Melatonin["Melatonin"]
style MMP2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style Melatonin fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| SIRT1 | upregulates | gene | 0.95 |
| Alzheimer's Disease | treats | disease | 0.90 |
| Alzheimer'S Disease | treats | disease | 0.90 |
| Polycystic Ovary Syndrome | treats | disease | 0.90 |
| Oxidative Stress | inhibits | process | 0.85 |
| Neuroinflammation | inhibits | process | 0.85 |
| Oxidative Stress | modulates | process | 0.85 |
| Neuroinflammation | modulates | process | 0.85 |
| SIRT1 | activates | gene | 0.85 |
| APOPTOSIS | suppresses | process | 0.85 |
| Mitochondrial Membrane Potential | protects_against | biomarker | 0.84 |
| MMP2 | targets | gene | 0.80 |
| NR3C1 | targets | gene | 0.80 |
| Amyloidosis | modulates | process | 0.80 |
| Alzheimer'S Disease | protects_against | disease | 0.80 |
| Autism Spectrum Disorder | treats | disease | 0.80 |
| Circadian Rhythmicity | marker_of | biological_process | 0.80 |
| Circadian | activates | entity | 0.70 |
| Circadian | inhibits | entity | 0.70 |
| Circadian | regulates | entity | 0.70 |
| Circadian | interacts_with | entity | 0.70 |
| Sox2 | upregulates | transcription_factor | 0.70 |
| Oct4 | upregulates | transcription_factor | 0.70 |
| Nanog | upregulates | transcription_factor | 0.70 |
| MTNR1A | binds_to | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Circadian Glymphatic Rescue Therapy (Melatonin-focused) | 0.546 | neurodegeneration | Sleep disruption as cause and consequenc |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Prevalence of symptoms of depression, anxiety, insomnia, posttraumatic stress di [PMID:33285346] | Cénat JM, Blais-Rochette C, Kokou-Kpolou | Psychiatry Res | 2021 | 1 |
| Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Seque [PMID:32822576] | Maynard A, McCoach CE, Rotow JK, Harris | Cell | 2020 | 1 |
| The Ca(2+) Sensor SCaBP3/CBL7 Modulates Plasma Membrane H(+)-ATPase Activity and [PMID:30962395] | Yang Y, Wu Y, Ma L, Yang Z, Dong Q, Li Q | Plant Cell | 2019 | 1 |
| Sleep drives metabolite clearance from the adult brain. [PMID:24136970] | Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th | Science | 2013 | 1 |
| Impact of preinterventional plaque composition and eccentricity on late-acquired [PMID:22936019] | Sato T, Kameyama T, Noto T, Nozawa T, In | Coron Artery Dis | 2012 | 1 |
| Melatonin Promotes the Synthesis and Secretion of Growth Hormone in the Adenohyp [PMID:41870323] | ["Zheng Y", "Chen Q", "Guo H", "Zhang Y" | Journal of pineal research | 2026 | 0 |
| Screening natural raw materials and product development for improving insomnia b [PMID:41578474] | ["Yue L", "Jiao Q", "Li J", "Lu Y", "Yi | Medicine | 2026 | 0 |
| Pharmacological modulation of MRAP2 protein on murine melatonin receptor signali [PMID:40510472] | Song W, Li Y, Xu H, Zhang Y, Liu L, Li Y | Frontiers in endocrinology | 2025 | 0 |
| Regulation of therapeutic protein release in response to circadian biomarkers. [PMID:41198646] | Franko N, Li S, Galvan S, Csorba Z, Teix | Nature communications | 2025 | 0 |
| Polymorphisms in MTNR1A (rs2119882) and CLOCK (rs1801260) genes are associated w [PMID:40705802] | Chi Y, Yang X, Deng D, Li P, Zhang Y | PloS one | 2025 | 0 |
| Finger friction with leather and seam of new and used softballs with and without [PMID:35678234] | ["Kinoshita H"] | Sports biomechanics | 2024 | 0 |
| System-Level Strategies to Improve Home Dialysis: Policy Levers and Quality Init [PMID:37678234] | ["Watnick S", "Blake P", "Mehrotra R", " | Clinical journal of the Americ | 2023 | 0 |
| Recommendations for risk minimization when using Janus kinase inhibitors for the [PMID:37345890] | ["Wohlrab J", "Kegel T", "Gro\u00dfe R", | Journal der Deutschen Dermatol | 2023 | 0 |
| In Vitro Anticancer Activity of the Light Stable Zinc Isotope (64Zn) Compounds. [PMID:36456123] | ["Novak P", "Balakin A", "Temnik M"] | Anticancer research | 2022 | 0 |
| A long-term follow-up study on otoacoustic emissions testing in paediatric patie [PMID:31234890] | ["Reiterer E", "Reider S", "Lackner P", | Malaria journal | 2019 | 0 |
| Severe refractory idiopathic warm autoimmune haemolytic anaemia responsive to co [PMID:30567234] | ["Neave L", "Wilson A", "Lissack M", "Sc | BMJ case reports | 2018 | 0 |
| Metformin and lung cancer risk in patients with type 2 diabetes mellitus. [PMID:28456789] | ["Tseng C"] | Oncotarget | 2017 | 0 |