concept

MELATONIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MELATONIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

273Connections

5Hypotheses

4Analyses

50Outgoing

50Incoming

9Experiments

4Debates

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💡 Concept Info

Name	MELATONIN
Key Genes/Proteins	ACSL4, AMYLOID, AMYLOID-BETA, APP, AQP4
Related Diseases	ACETYLCHOLINE, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

therapeutic · 4539 words

→

Pathway Diagram

graph TD
    MELATONIN["MELATONIN"]
    style MELATONIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    MELATONIN -->|"treats"| Sepsis_Induced_Acute_Kidney_In["Sepsis-Induced Acute Kidney Injury"]
    MELATONIN -->|"upregulates"| SOX2([SOX2])
    MELATONIN -->|"upregulates"| OCT4([OCT4])
    MELATONIN -->|"upregulates"| NANOG([NANOG])
    MELATONIN -->|"upregulates"| POU5F1([POU5F1])
    MELATONIN -.->|"protects against"| mitochondrial_dysfunction(mitochondrial dysfunction)
    MELATONIN -->|"treats"| Alzheimer_s_Disease["Alzheimer's Disease"]
    MELATONIN -->|"activates"| Mitophagy["Mitophagy"]
    MELATONIN -.->|"biomarker for"| CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    MELATONIN -->|"modulates"| Skin_Fibroblasts["/Skin Fibroblasts/"]
    Circadian_Clock_Genes["Circadian Clock Genes"] -->|"regulates"| MELATONIN
    Circadian["Circadian"] -->|"interacts"| MELATONIN
    RPL18A([RPL18A]) -->|"regulates"| MELATONIN

Outgoing (193)

Target	Relation	Type	Str
SIRT1	upregulates	gene	0.95
mitochondrial_transfer	promotes	mechanism	0.95
CIRCADIAN RHYTHM	biomarker_for	entity	0.90
Alzheimer'S Disease	treats	disease	0.90
Alzheimer's Disease	treats	disease	0.90
mitochondrial dysfunction	protects_against	phenotype	0.90
Polycystic Ovary Syndrome	treats	disease	0.90
Nrf2	activates	pathway	0.90
sleep consolidation	activates	phenotype	0.90
APOPTOSIS	suppresses	process	0.85
mitochondrial_dysfunction	inhibits	mechanism	0.85
Oxidative Stress	modulates	process	0.85
Neuroinflammation	modulates	process	0.85
oxidative stress	inhibits	process	0.85
OBSTRUCTIVE SLEEP APNEA SYNDROME	biomarker_for	entity	0.85
SIRT1	activates	gene	0.85
Neuroinflammation	inhibits	process	0.85
Oxidative Stress	inhibits	process	0.85
Mitochondrial Membrane Potential	protects_against	biomarker	0.84
mtDNA damage	protects_against	phenotype	0.82
mitochondrial DNA release	inhibits	mechanism	0.80
MMP2	targets	gene	0.80
NR3C1	targets	gene	0.80
Amyloidosis	modulates	process	0.80
CREB/RCAN1	activates	pathway	0.80
NRF2	activates	protein	0.80
mitophagy	regulates	pathway	0.80
Circadian Rhythmicity	marker_of	process	0.80
Nrf2	activates	pathway	0.80
postoperative sleep disorder	treats	disease	0.80
Alzheimer'S Disease	protects_against	disease	0.80
Autism Spectrum Disorder	treats	disease	0.80
NF-κB	inhibits	pathway	0.75
Oct4	upregulates	transcription_factor	0.70
Sox2	upregulates	transcription_factor	0.70
Alzheimer's disease	treats	disease	0.70
FERROPTOSIS	protects_against	phenotype	0.70
AChE	modulates	enzyme	0.70
AMPK/ULK1	inhibits	pathway	0.70
circadian rhythm synchronization	activates	process	0.70
BACE1	modulates	gene	0.70
TAU	phosphorylates	protein	0.70
MITOPHAGY	treats	phenotype	0.70
MT1 receptor	activates	protein	0.70
reactive oxygen species	inhibits	process	0.70
Nanog	upregulates	transcription_factor	0.70
BACE1	inhibits	gene	0.70
PS-NP-induced neurodegeneration	protects_against	disease	0.70
Alzheimer's disease	protects_against	disease	0.70
cGAS-STING1-TBK1	activates	pathway	0.70

Incoming (80)

Source	Relation	Type	Str
36917314	prevents	paper	0.90
36917314	controls	paper	0.90
AGING	associated_with	gene	0.90
41594924	promotes	paper	0.90
41594924	selectively accumulates in	paper	0.90
41594924	scavenges	paper	0.90
41594924	activates antioxidant defenses via	paper	0.90
41594924	regulates mitochondrial dynamics through	paper	0.90
41594924	promotes mitophagy via	paper	0.90
41594924	promotes pro-survival autophagy by inhibiting	paper	0.90
41594924	activates transcription via	paper	0.90
41594924	regulates mitochondrial dynamics via	paper	0.90
37802998	relieves	paper	0.90
37802998	restores	paper	0.90
37802998	improves depression outcomes by regulating	paper	0.90
ORAS	modulates	disease	0.80
NR3C1	involved_in	gene	0.70
MMP2	involved_in	gene	0.70
SEROTONIN	causes	phenotype	0.70
Circadian	interacts_with	entity	0.70
RPL18A	regulates	gene	0.70
AMYLOID	stabilizes	protein	0.70
APP	treats	gene	0.70
TAU	treats	protein	0.70
NEURODEGENERATION	stabilizes	phenotype	0.70
STING	inhibits	gene	0.65
PINK1	treats	gene	0.65
36917314	proposed to play a role in flushing	paper	0.60
NEURON	targets	cell_type	0.60
41594924	inhibits	paper	0.60
APP	stabilizes	gene	0.60
41594924	offers mitochondria-targeting strategy for treatment of	paper	0.60
41594924	restores	paper	0.60
41594924	offers mitochondria-targeting strategy for	paper	0.60
36917314	flushes	paper	0.60
ENDOTHELIAL CELLS	associated_with	cell_type	0.50
SYNAPTIC LOSS	associated_with	phenotype	0.50
ASTROCYTES	associated_with	cell_type	0.50
BIPOLAR DISORDER	associated_with	disease	0.50
AMYLOID-BETA	associated_with	protein	0.50
SCHIZOPHRENIA	associated_with	disease	0.50
PHAGOCYTOSIS	associated_with	phenotype	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
IL6	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
EPITHELIAL CELLS	associated_with	cell_type	0.45
CYTOKINES	associated_with	phenotype	0.45
NRF2 PATHWAY	associated_with	pathway	0.45
PRAMIPEXOLE	associated_with	drug	0.45
MEMANTINE	associated_with	drug	0.45

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Circadian Glymphatic Rescue Therapy (Melatonin-focused)	0.712	neurodegeneration	Sleep disruption as cause and consequenc
Circadian-Phase Anchored Low-Dose Melatonin for Prevention	0.585	-	What is the optimal dosage and timing of
Time-Restricted High-Dose Melatonin for Acute Neuroprotectio	0.445	-	What is the optimal dosage and timing of
Timed Melatonin Administration Exploits Circadian Vulnerabil	0.000	-	Microglia-astrocyte crosstalk amplificat
Circadian Melatonin Therapy for Glymphatic Enhancement	0.000	-	Perivascular spaces and glymphatic clear

Mentioning Analyses (4)

Scientific analyses that reference this entity

What is the optimal dosage and timing of melatonin administration for AD prevent

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.735

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.756

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.729

Sleep disruption as cause and consequence of neurodegeneration

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (9)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co	clinical	Alzheimer's Disease	0.900	0.50	aortic endothelial cells	proposed	$6,550,000
Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention Trial	clinical	Neurodegeneration	0.400	0.50	human	proposed	$3,900,000
DLB Cognitive Fluctuation Mechanism Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$6,550,000
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
NPH Glymphatic System Interaction Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Sleep and Circadian Dysfunction as Driver of Neurodegeneration	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Sleep Disruption and Alzheimer's Disease — mechanism and intervention	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Sleep and Respiratory Network Interaction in ALS — Experiment Design	clinical	ALS	0.400	0.50	human	proposed	$5,460,000

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Prevalence of symptoms of depression, anxiety, insomnia, posttraumatic stress di [PMID:33285346]	Cénat JM, Blais-Rochette C, Kokou-Kpolou	Psychiatry Res	2021	1
Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Seque [PMID:32822576]	Maynard A, McCoach CE, Rotow JK, Harris	Cell	2020	1
The Ca(2+) Sensor SCaBP3/CBL7 Modulates Plasma Membrane H(+)-ATPase Activity and [PMID:30962395]	Yang Y, Wu Y, Ma L, Yang Z, Dong Q, Li Q	Plant Cell	2019	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Impact of preinterventional plaque composition and eccentricity on late-acquired [PMID:22936019]	Sato T, Kameyama T, Noto T, Nozawa T, In	Coron Artery Dis	2012	1
Melatonin Promotes the Synthesis and Secretion of Growth Hormone in the Adenohyp [PMID:41870323]	["Zheng Y", "Chen Q", "Guo H", "Zhang Y"	Journal of pineal research	2026	0
Screening natural raw materials and product development for improving insomnia b [PMID:41578474]	["Yue L", "Jiao Q", "Li J", "Lu Y", "Yi	Medicine	2026	0
Pharmacological modulation of MRAP2 protein on murine melatonin receptor signali [PMID:40510472]	Song W, Li Y, Xu H, Zhang Y, Liu L, Li Y	Frontiers in endocrinology	2025	0
Regulation of therapeutic protein release in response to circadian biomarkers. [PMID:41198646]	Franko N, Li S, Galvan S, Csorba Z, Teix	Nature communications	2025	0
Polymorphisms in MTNR1A (rs2119882) and CLOCK (rs1801260) genes are associated w [PMID:40705802]	Chi Y, Yang X, Deng D, Li P, Zhang Y	PloS one	2025	0
Electroconvulsive Therapy Versus Repetitive Transcranial Magnetic Stimulation in [PMID:38456234]	Katarzyna Popiolek; Tor Arnison; Robert	The journal of ECT	2024	0
Finger friction with leather and seam of new and used softballs with and without [PMID:35678234]	["Kinoshita H"]	Sports biomechanics	2024	0
System-Level Strategies to Improve Home Dialysis: Policy Levers and Quality Init [PMID:37678234]	["Watnick S", "Blake P", "Mehrotra R", "	Clinical journal of the Americ	2023	0
Recommendations for risk minimization when using Janus kinase inhibitors for the [PMID:37345890]	["Wohlrab J", "Kegel T", "Gro\u00dfe R",	Journal der Deutschen Dermatol	2023	0
In Vitro Anticancer Activity of the Light Stable Zinc Isotope (64Zn) Compounds. [PMID:36456123]	["Novak P", "Balakin A", "Temnik M"]	Anticancer research	2022	0
Fascia iliaca compartment block. [PMID:33456890]	N O'Reilly; M Desmet; R Kearns	BJA education	2021	0
A long-term follow-up study on otoacoustic emissions testing in paediatric patie [PMID:31234890]	["Reiterer E", "Reider S", "Lackner P",	Malaria journal	2019	0
Severe refractory idiopathic warm autoimmune haemolytic anaemia responsive to co [PMID:30567234]	["Neave L", "Wilson A", "Lissack M", "Sc	BMJ case reports	2018	0
Metformin and lung cancer risk in patients with type 2 diabetes mellitus. [PMID:28456789]	["Tseng C"]	Oncotarget	2017	0

Debates (4)

Multi-agent debates referencing this entity

What is the optimal dosage and timing of melatonin administration for AD prevent

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

What are the mechanisms underlying sleep disruption as cause and consequence of

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning MELATONIN in their description or question text

No additional research found