Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPL6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | RPL6 |
| Full Name | Ribosomal Protein L6 |
| Chromosome | 12q24.31 |
| Protein Type | Ribosomal protein, 60S large subunit |
| Function | is a component of the 60S large ribosomal subunit and plays a critical role in protein synthesis within all eukaryotic cells, including neurons. |
| Molecular Weight | 32.5 kDa |
| UniProt ID | P62888 |
| NCBI Gene ID | 6128 |
| GeneCards | RPL6 |
| Human Protein Atlas | RPL6 |
| Peptidyl Transferase Activity | RPL6 contributes to the peptidyl transferase center (PTC) of the ribosome, where peptide bonds are formed between amino acids during protein synthesis |
| Ribosome Structure | RPL6 helps maintain the structural integrity of the 60S subunit, interacting with rRNA and other ribosomal proteins to form a stable functional ribosome |
| Translation Initiation | The 60S subunit joins the 40S pre-initiation complex to form the 80S ribosome, which is essential for the initiation of protein synthesis in eukaryotes |
| Translation Elongation | During the elongation phase, RPL6 participates in the translocation of tRNA molecules between the A, P, and E sites of the ribosome |
| Global Translation Impairment | Post-mortem brain studies of AD patients reveal decreased levels of ribosomal proteins and reduced translational capacity in affected brain regions, particularly the hippocampus and prefrontal cortex |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RPL6["RPL6"]
neurodegeneration["neurodegeneration"]
RPL6 -->|"implicated_in"| neurodegeneration
style RPL6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RPL6 in their description or question text
No additional research found