gene

RPS14

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RPS14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	RPS14
Chromosome	5q
Function	encodes an essential ribosomal protein component of the 40S small ribosomal subunit.
Molecular Weight	16 kDa
Amino Acids	151 aa
Ensembl ID	ENSG00000129864
GeneCards	RPS14
Human Protein Atlas	RPS14
rRNA binding and stabilization	RPS14 interacts with 18S rRNA, stabilizing the rRNA structure
mRNA binding	The protein participates in the mRNA entry channel, facilitating mRNA binding and scanning
Translation initiation	RPS14 contributes to the formation of the pre-initiation complex (43S PIC)
Small subunit assembly	Proper RPS14 incorporation is essential for 40S biogenesis
Haploinsufficiency	Most pathogenic RPS14 variants create null alleles, leading to reduced RPS14 protein levels
Impaired ribosome biogenesis	Reduced RPS14 availability compromises 40S ribosomal subunit assembly
Selective translational defect	Erythroid progenitor cells are particularly sensitive to ribosomal stress due to high translational demands
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RPS14 Gene - Ribosomal Protein S14

gene · 1172 words

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Pathway Diagram

graph TD
    RPS14["RPS14"]
    neurodegeneration["neurodegeneration"]
    RPS14 -->|"implicated_in"| neurodegeneration
    style RPS14 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning RPS14 in their description or question text

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