Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RRAGC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RRAGC |
| Function | Unlike classical Ras GTPases, Rag GTPases do not directly regulate cell proliferation but instead control the nutrient-sensitive mTORC1 pathway |
| Subcellular Localization | **Autophagy Regulation** Rag GTPases are crucial regulators of autophagy: - ** |
| Pathways | mTOR, MTOR |
| Ensembl ID | ENSG00000136244 |
| GeneCards | RRAGC |
| Human Protein Atlas | RRAGC |
| GTP-bound state | Active, promotes mTORC1 recruitment to lysosomes |
| GDP-bound state | Inactive, prevents mTORC1 signaling |
| GTPase cycle | Regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) |
| Heterodimer formation | RRAGC forms heterodimers with RRAGA or RRAGB |
| Lysosomal recruitment | The Rag heterodimer recruits mTORC1 to the lysosomal surface where it is activated |
| Amino acid sensing | Rag GTPases sense amino acid levels in the lysosomal lumen |
| Ragulator complex | RRAGC interacts with the Ragulator complex (LAMTOR1-5) for proper localization |
| mTORC1 inhibition | Inactive Rag GTPases allow mTORC1 to release, enabling autophagy initiation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RRAGC["RRAGC"]
neurodegeneration["neurodegeneration"]
RRAGC -->|"implicated_in"| neurodegeneration
style RRAGC fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RRAGC in their description or question text
No additional research found