Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RTN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RTN2 (Reticulon 2/Nogo) is a membrane protein involved in ER morphology and axonal regeneration inhibition, implicated in ALS and MS.
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| Gene Symbol | RTN2 |
| Full Name | Reticulon 2 (Nogo) |
| Aliases | Reticulon 2/Nogo |
| Chromosome | 19p13.3 |
| Function | is a member of the reticulon family of membrane proteins with critical roles in shaping the endoplasmic reticulum (ER) network and inhibiting axonal regeneration in the central nervous system. |
| Primary Expression | the nervous system |
| Amino Acids | 66 aa |
| UniProt ID | Q9NQC3 |
| NCBI Gene ID | 10228 |
| Ensembl ID | ENSG00000155050 |
| OMIM | 604215 |
| GeneCards | RTN2 |
| Human Protein Atlas | RTN2 |
| Associated Diseases | ALS, Alzheimer's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RTN2["RTN2"]
neurodegeneration["neurodegeneration"]
RTN2 -->|"implicated_in"| neurodegeneration
style RTN2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RTN2 in their description or question text
No additional research found