Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Reactive Astrocyte: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | contributes_to | disease | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RGFP966 | suppresses | drug | 0.95 |
| Disease, Injury And Aging | causes | process | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| GFAP-Positive Reactive Astrocyte Subtype Delineation | 0.754 | alzheimers | SEA-AD Gene Expression Profiling — Allen |
| Circadian Rhythm Entrainment of Reactive Astrocytes | 0.722 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
| GFAP-Bearing Circulating Extracellular Vesicles Originating | 0.665 | - | What blood-brain barrier permeability ch |
| GFAP-positive reactive astrocyte states as mediators of regi | 0.604 | neurodegeneration | AD Master Plan preregistration: GFAP |
| AQP4 Missorting in Reactive Astrocytes Drives Glymphatic Fai | 0.580 | neurodegeneration | What are the specific molecular mechanis |
| Reactive astrocyte glutamate-handling failure sustains dendr | 0.490 | neurodegeneration | Does tau dendritic missorting persist in |
| Reactive astrocytes and cholinesterase-rich low-acetylcholin | 0.440 | neurodegeneration | What determines the temporal sequence of |
| Glycolytic Inhibition Selectively Blocks Reactive Astrocyte | 0.000 | - | Microglia-astrocyte crosstalk amplificat |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Circadian gene expression effects of SD vs ketamine | exploratory | depression | 0.950 | 0.00 | C57BL/6J mice | proposed | N/A |
| iPSC-NPC effects on astrocytes in vitro ICH model | exploratory | intracerebral hemorrhage | 0.900 | 0.00 | in vitro ICH cell culture mode | completed | N/A |
| CLOCK/BMAL1 regulation of ICC autophagy in GERD model | exploratory | gastroesophageal reflux diseas | 0.900 | 0.00 | primary esophageal interstitia | proposed | N/A |
| Cognitive impact of TDP-43 pathology in AD patients | clinical | Alzheimer's disease | 0.700 | 0.00 | human patients | completed | N/A |
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Brainstem Circuit Modulation for PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Non-Dopaminergic Neurotransmitter Degeneration in PD - Experiment Desi | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Recept [PMID:28709002] | Nabet BY, Qiu Y, Shabason JE, Wu TJ, Yoo | Cell | 2017 | 412 |
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science | 2023 | 186 |
| BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. [PMID:40269168] | Ruan W, Li T, Bang IH, Lee J, Deng W, Ma | Nature | 2025 | 1 |
| Obstructive sleep apnea syndrome, orexin, and sleep-wake cycle: The link with th [PMID:39864923] | Fernandes M, Liguori C | Handb Clin Neurol | 2025 | 1 |
| Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases. [PMID:39728504] | Hussain Y, Dar MI, Pan X | Metabolites | 2024 | 1 |
| Circadian rhythm regulates the function of immune cells and participates in the [PMID:38678017] | Zeng Y, Guo Z, Wu M, Chen F, Chen L | Cell Death Discov | 2024 | 1 |
| Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases. [PMID:32705594] | Pan X, Mota S, Zhang B | Adv Exp Med Biol | 2020 | 1 |
| Independent and interactive contributions of white matter hyperintensities and A [PMID:41906163] | Dario Bachmann; Christoph Gericke; Maha | Alzheimer's research & the | 2026 | 0 |
| Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associate [PMID:41905188] | Cetindag AC, Schipke CG, Esselmann H, Kr | The journal of prevention of A | 2026 | 0 |
| BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/ [PMID:41909150] | Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wa | Biochemistry and biophysics re | 2026 | 0 |
| Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830] | Kang J, Son Y, Yim Y, Cho H, Kim J et al | J Adv Res | 2026 | 0 |
| Potential diagnostic markers in Alzheimer's disease: current perspectives and fu [PMID:40911035] | Zheng M, Wang S, Jia J | Neurodegener Dis Manag | 2026 | 0 |
| Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646] | Lin L, Liang X, Xu Z, Li Y, Guo Z et al. | Biomaterials | 2026 | 0 |
| MAO-B status in alcohol use disorder: a [(11)C]SL25.1188 PET imaging study of pu [PMID:41291188] | Best LM, Truong J, McCluskey T, Meyer JH | Mol Psychiatry | 2026 | 0 |
| The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525] | Sica V, Sato T, Tsialtas I, Hernandez S, | J Biol Rhythms | 2026 | 0 |
| Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008] | Tsameret S, Froy O, Matz Y, Landau Z, Tw | Diabetologia | 2026 | 0 |
| Bmal1 Regulates Vascular Calcification via Noncanonical Circadian Pathway-Brief [PMID:41608773] | He M, Sun Y, Tang C, Huang F, Zhu Z et a | Arterioscler Thromb Vasc Biol | 2026 | 0 |
| Association between sleep duration and fluid biomarkers of Alzheimer's disease: [PMID:41610733] | Young VM, Zeynoun J, Ruiz Laza A, Salard | Sleep Med Rev | 2026 | 0 |
| Injectable anti-inflammatory, antioxidant supramolecular nanofiber hydrogel for [PMID:41624514] | Liu A, Sheng K, Li H, Zhao X, Zhang X et | Mater Today Bio | 2026 | 0 |
| NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopat [PMID:41650822] | López-Sampere Y, Mengod Soler P, Roca-Pe | Redox Biol | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Reactive Astrocyte in their description or question text
Score: 0.490 · neurodegeneration · 2026-04-25
Aβ leaves astrocytes in a reactive, low-EAAT2 state that increases extrasynaptic NMDA receptor drive, allowing dendritic
Score: 0.440 · neurodegeneration · 2026-04-25
Reactive astrocytes may degrade acetylcholine and destabilize cortical network states, secondarily creating conditions p
Score: 0.000 · unknown disease · 2026-04-28
Since reactive astrocytes require increased glucose metabolism to produce complement proteins and chemokines, selective