Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Reelin signaling / cytoskeletal regulation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| RELN | participates_in | gene | 0.44 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Reelin-Mediated Cytoskeletal Stabilization Protocol | 0.448 | neurodegeneration | Selective vulnerability of entorhinal co |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.484
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Loss of endothelial CD2AP causes sex-dependent cerebrovascular dysfunction. [PMID:39892386] | Vandal M, Institoris A, Reveret L, Korin | Neuron | 2025 | 1 |
| Protective genetic variants against Alzheimer's disease. [PMID:40409316] | Marino C, Malotaux V, Giudicessi A, Agui | Lancet Neurol | 2025 | 1 |
| Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional [PMID:39232006] | Serafin DS, Harris NR, Bálint L, Douglas | Nat Commun | 2024 | 1 |
| Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Devel [PMID:32604886] | Jossin Y | Biomolecules | 2020 | 1 |
| Neuronal migration. [PMID:11429281] | Lambert de Rouvroit C, Goffinet AM | Mech Dev | 2001 | 1 |
| Modulation of apolipoprotein E receptor-2 by ApoE4, amyloid β-peptide, reelin, a [PMID:41858499] | ["Barger S", "Moerman-Herzog A"] | Frontiers in molecular neurosc | 2026 | 0 |
| The Potential Molecular Mechanisms and Key Genes of Early Deterioration of Paren [PMID:41863408] | ["Cen G", "Li J", "Wang J", "Chen Y", "L | Current neurovascular research | 2026 | 0 |
| RELN biallelic variant as a candidate risk factor in a consanguineous Pakistani [PMID:41785923] | ["Hashmi A", "Harripaul R", "Muhammad T" | Journal of affective disorders | 2026 | 0 |
| Temporal and Spatial Gene Expression Dynamics in Neonatal HI Hippocampus with Fo [PMID:41677619] | ["Smith M", "Natarajan E", "Lizama-Valen | Cells | 2026 | 0 |
| Migration of dI5 Reelin-Lmx1b-Zfhx3 and Disabled-1-Lmx1b-Zfhx3 neurons contribut [PMID:41890024] | ["Yvone G", "Chavez-Martinez C", "Mekonn | bioRxiv : the preprint server | 2026 | 0 |
| Whisking Behaviour Reveals Stronger Evidence of Habituation in Homozygous Reeler [PMID:41844513] | ["Simanaviciute U", "Cetin A", "Guy J", | Genes, brain, and behavior | 2026 | 0 |
| Reln haploinsufficiency enhances fentanyl-induced locomotion and striatal activi [PMID:41890027] | ["Litif C", "Libster A", "Desfor S", "Hu | bioRxiv : the preprint server | 2026 | 0 |
| Immunoglobulin allotypes and [PMID:41848375] | ["Pandey J", "Namboodiri A", "Nietert P" | Journal of Alzheimer's disease | 2026 | 0 |
| Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052] | ["Burdman G", "Akkaoui J", "Colon N", "P | Neurology international | 2026 | 0 |
| Genetic or therapeutic disruption of the Reelin/Apoer2 signaling pathway improve [PMID:40073057] | ["Calvier L", "Wasser C", "Solow E", "Wu | Proceedings of the National Ac | 2025 | 0 |
| Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheime [PMID:41035073] | Castanho I, Naderi Yeganeh P, Boix CA, M | Molecular neurodegeneration | 2025 | 0 |
| Glutamatergic argonaute2 promotes the formation of the neurovascular unit in mic [PMID:39999211] | Sona C, Yeh YT, Li Y, Liu X, Ghosh A, Hi | Science signaling | 2025 | 0 |
| APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodege [PMID:40307424] | ["Vanherle S", "Janssen A", "Guti\u00e9r | Molecular psychiatry | 2025 | 0 |
| Protective Genes Against Alzheimer's Disease: Case Review and Therapeutic Implic [PMID:40321438] | Hossain N, Jeong Y | Dementia and neurocognitive di | 2025 | 0 |
| Biomolecular Aspects of Reelin in Neurodegenerative Disorders: An Old Candidate [PMID:40806482] | Balzamino BO, Biamonte F, Micera A | International journal of molec | 2025 | 0 |