gene

RELN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RELN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

253Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

RELN is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, protects against, implicated in. Associated with AD, AMI, Aging. Connected to 82 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RELN
Full Name	Reelin
Chromosome	7q22.1
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	The protein contains an N-terminal signal peptide followed by 8 reelin repeat domains (R1-R8), each approximately 350 amino acids in length.
Mechanism of Action	Drugs targeting RELN would primarily work by enhancing reelin expression or signaling through its receptors (VLDLR and ApoER2) to promote neuronal migration, synaptic plasticity, and cognitive function. Alternatively, pathway modulators could enhance downstream signaling cascades (Dab1-mediated pathways) to compensate for reelin deficiency or dysfunction.
Primary Expression	migrating neurons and mature neurons, VLDLR mediates reelin signaling involved in neuronal positioning and synaptic function [4](https://pubmed
Druggability	Low (0.33)
Clinical Stage	Approved
Molecular Weight	400 kDa
Amino Acids	350 aa
Pathways	Epigenetic, Reelin-Mediated Cytoskeletal Stabilization Protoco
UniProt ID	P78509
Ensembl ID	ENSG00000189056
GeneCards	RELN
Human Protein Atlas	RELN
Associated Diseases	AD, ALS, AMI, Alzheimer, Alzheimer disease
Known Drugs/Compounds	valproic acid
Interactions	DNMT1, DNMT3B, BDNF, DAB1, PSEN1, TAU
SciDEX Target	View Target Profile (9 clinical trials)
SciDEX Hypotheses	Reelin-Mediated Cytoskeletal Stabilization Protoco
KG Connections	253 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: RELN — AlphaFold P78509 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RELN["RELN"] -->|"regulates"| Reelin_Mediated_Cytoskeletal_S["Reelin-Mediated Cytoskeletal Stabilization Protoco"]
    RELN["RELN"] -->|"protects against"| Alzheimer["Alzheimer"]
    RELN["RELN"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    RELN["RELN"] -->|"interacts"| Schizophrenia["Schizophrenia"]
    RELN["RELN"] -->|"therapeutic target"| Dementia["Dementia"]
    RELN["RELN"] -->|"interacts"| Alzheimer_1["Alzheimer"]
    h_d2df6eaf["h-d2df6eaf"] -->|"therapeutic target"| RELN["RELN"]
    h_d2df6eaf_2["h-d2df6eaf"] -->|"targets"| RELN["RELN"]
    JUN["JUN"] -->|"protects against"| RELN["RELN"]
    APOE["APOE"] -->|"associated"| RELN["RELN"]
    style RELN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (159)

Target	Relation	Type	Str
DENDRITIC GROWTH	regulates	entity	0.95
DENDRITIC SPINE FORMATION	regulates	entity	0.95
SYNAPTOGENESIS	regulates	entity	0.95
VLDLR	binds_to	entity	0.95
APOE	binds_to	entity	0.95
VLDLR	binds	protein	0.95
Apoer2	binds	protein	0.95
superficial dorsal horn	expressed_in	brain_region	0.95
NEURONAL MIGRATION	regulates	entity	0.95
SYNAPTIC PLASTICITY	regulates	entity	0.95
dendritic growth and branching	regulates	process	0.90
DAB1	interacts_with	protein	0.90
neuron positioning in dorsal horn	regulates	process	0.90
neuronal lamination	regulates	process	0.90
ALZHEIMER'S DISEASE	associated_with	entity	0.90
ALZHEIMER'S DISEASE	implicated_in	entity	0.90
Heart Development	involved_in	process	0.85
Heart Injury Repair	involved_in	process	0.85
Neuronal Architecture Formation	regulates	process	0.85
dI5 neuron migration	mediates	process	0.85
synaptic function	regulates	process	0.85
Lissencephaly	associated_with	disease	0.85
AUTISM	implicated_in	entity	0.85
SCHIZOPHRENIA	implicated_in	entity	0.85
BIPOLAR DISORDER	implicated_in	entity	0.85
DEPRESSION	implicated_in	entity	0.85
EPILEPSY	implicated_in	entity	0.85
Alzheimer'S Disease	protects_against	disease	0.85
Alzheimer'S Disease	risk_factor_for	disease	0.85
Lissencephaly	causes	disease	0.80
disease progression	modulates	phenotype	0.80
lamina V	contributes_to	brain_region	0.80
lamina I positioning defect	implicated_in	phenotype	0.80
regenerative response	drives	process	0.80
CORTEX	expressed_in	entity	0.80
HIPPOCAMPUS	expressed_in	entity	0.80
Alzheimer'S Disease	associated_with	disease	0.80
reelin_protein	encodes	protein	0.80
heart development	regulates	process	0.75
microglia regenerative response	upregulates	process	0.75
Reelin-Mediated Cytoskeletal Stabilization Protoco	regulates	mechanism	0.70
injury repair	promotes	process	0.70
Alzheimer's Disease	risk_factor_for	disease	0.70
anti-HSV1-gD antibody levels	modulates	phenotype	0.65
Alzheimer	protects_against	disease	0.65
Neurodegeneration	regulates	disease	0.65
Schizophrenia	interacts_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65

Incoming (94)

Source	Relation	Type	Str
CDH5	regulates	protein	0.95
SRC	interacts_with	entity	0.90
FYN	interacts_with	entity	0.90
CDH5	mediates	protein	0.90
h-d2df6eaf	targets_gene	hypothesis	0.90
h-d2df6eaf	targets	hypothesis	0.80
Km Allotype	interacts_with	biomarker	0.75
APOE	co_mentioned_with	gene	0.60
JUN	protects_against	gene	0.60
APOE	associated_with	gene	0.60
DAB1	interacts_with	gene	0.60
DHX9	associated_with	gene	0.60
KCNT1	therapeutic_target	gene	0.60
KCNQ2	therapeutic_target	gene	0.60
SCN1A	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
APOE4	associated_with	gene	0.60
REELIN	protects_against	gene	0.60
TAU	activates	gene	0.60
DAB1	activates	gene	0.60
GAIN	activates	gene	0.60
REELIN	activates	gene	0.60
LDLR	interacts_with	gene	0.60
valproic acid	activates	compound	0.60
valproic acid	inhibits	compound	0.60
APOE	protects_against	gene	0.60
CAV1	associated_with	gene	0.60
CAV1	interacts_with	gene	0.60
CAV1	implicated_in	gene	0.60
APOE	biomarker_for	gene	0.60
CLU	biomarker_for	gene	0.60
KM	interacts_with	phenotype	0.60
APOE	interacts_with	gene	0.60
ATP8B1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
NPTX2	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60
PLCG2	interacts_with	gene	0.60
RAB10	interacts_with	gene	0.60
MET	activates	gene	0.60
CAV1	targets	gene	0.60
NME1	targets	gene	0.60
NME1	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
MIRNAS	regulates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
PHAGOCYTOSIS	protects_against	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
MICROGLIA	protects_against	gene	0.60
ALZHEIMER	protects_against	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Reelin-Mediated Cytoskeletal Stabilization Protocol	0.448	neurodegeneration	Selective vulnerability of entorhinal co

Mentioning Analyses (1)

Scientific analyses that reference this entity

Selective vulnerability of entorhinal cortex layer II neurons in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.484

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Loss of endothelial CD2AP causes sex-dependent cerebrovascular dysfunction. [PMID:39892386]	Vandal M, Institoris A, Reveret L, Korin	Neuron	2025	1
Protective genetic variants against Alzheimer's disease. [PMID:40409316]	Marino C, Malotaux V, Giudicessi A, Agui	Lancet Neurol	2025	1
Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional [PMID:39232006]	Serafin DS, Harris NR, Bálint L, Douglas	Nat Commun	2024	1
Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Devel [PMID:32604886]	Jossin Y	Biomolecules	2020	1
Neuronal migration. [PMID:11429281]	Lambert de Rouvroit C, Goffinet AM	Mech Dev	2001	1
Modulation of apolipoprotein E receptor-2 by ApoE4, amyloid β-peptide, reelin, a [PMID:41858499]	["Barger S", "Moerman-Herzog A"]	Frontiers in molecular neurosc	2026	0
The Potential Molecular Mechanisms and Key Genes of Early Deterioration of Paren [PMID:41863408]	["Cen G", "Li J", "Wang J", "Chen Y", "L	Current neurovascular research	2026	0
RELN biallelic variant as a candidate risk factor in a consanguineous Pakistani [PMID:41785923]	["Hashmi A", "Harripaul R", "Muhammad T"	Journal of affective disorders	2026	0
Temporal and Spatial Gene Expression Dynamics in Neonatal HI Hippocampus with Fo [PMID:41677619]	["Smith M", "Natarajan E", "Lizama-Valen	Cells	2026	0
Migration of dI5 Reelin-Lmx1b-Zfhx3 and Disabled-1-Lmx1b-Zfhx3 neurons contribut [PMID:41890024]	["Yvone G", "Chavez-Martinez C", "Mekonn	bioRxiv : the preprint server	2026	0
Whisking Behaviour Reveals Stronger Evidence of Habituation in Homozygous Reeler [PMID:41844513]	["Simanaviciute U", "Cetin A", "Guy J",	Genes, brain, and behavior	2026	0
Reln haploinsufficiency enhances fentanyl-induced locomotion and striatal activi [PMID:41890027]	["Litif C", "Libster A", "Desfor S", "Hu	bioRxiv : the preprint server	2026	0
Immunoglobulin allotypes and [PMID:41848375]	["Pandey J", "Namboodiri A", "Nietert P"	Journal of Alzheimer's disease	2026	0
Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052]	["Burdman G", "Akkaoui J", "Colon N", "P	Neurology international	2026	0
Genetic or therapeutic disruption of the Reelin/Apoer2 signaling pathway improve [PMID:40073057]	["Calvier L", "Wasser C", "Solow E", "Wu	Proceedings of the National Ac	2025	0
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheime [PMID:41035073]	Castanho I, Naderi Yeganeh P, Boix CA, M	Molecular neurodegeneration	2025	0
Glutamatergic argonaute2 promotes the formation of the neurovascular unit in mic [PMID:39999211]	Sona C, Yeh YT, Li Y, Liu X, Ghosh A, Hi	Science signaling	2025	0
APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodege [PMID:40307424]	["Vanherle S", "Janssen A", "Guti\u00e9r	Molecular psychiatry	2025	0
Protective Genes Against Alzheimer's Disease: Case Review and Therapeutic Implic [PMID:40321438]	Hossain N, Jeong Y	Dementia and neurocognitive di	2025	0
Biomolecular Aspects of Reelin in Neurodegenerative Disorders: An Old Candidate [PMID:40806482]	Balzamino BO, Biamonte F, Micera A	International journal of molec	2025	0

RELN

Understanding Entity Pages

Summary

Wiki Pages (21)

RELN Gene

Epigenetic Dysregulation in Neurodegeneration

Miller-Dieker Syndrome

Neuronal Migration

Entorhinal Cortex

Anterior Cingulate Cortex (ACC) Pyramidal Neurons

Precuneus Cortical Neurons

Cortical Layer 1 Neurons

NGN2 (Neurogenin-2)

Epigenetic Biomarkers in Neurodegenerative Diseases

CHD8 Gene

Entorhinal Cortex Stellate Cells (Layer II)

Cortical Pyramidal Neurons (Layers 2/3)

Gamma-Secretase Modulators

CDKL5 Gene

Hippocampal Cajal Retzius Cells Neurodegeneration

Section 143: Longitudinal Biomarker Monitoring Protocol in CBS/PSP

Olfactory Bulb Short-Axon Cells

MBD1 Protein — Methyl-CpG Binding Domain Protein 1

Layer 1 Cortical Interneurons