protein

S1PR1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about S1PR1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

S1PR1 couples primarily to Gi/o proteins, leading to activation of downstream signaling pathways including PI3K/Akt, MAPK/ERK, and Rac GTPases. This signaling regulates cell survival, proliferation, migration, and cytokine production.

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🔬 Protein Info

Gene Symbol	S1PR1PROTEIN
Chromosome	1p21
Protein Type	Receptor
Function	is a G protein-coupled receptor (GPCR) that binds the bioactive lipid sphingosine-1-phosphate (S1P).
Subcellular Localization	** \| Plasma membrane \|
Molecular Weight	43 kDa
Amino Acids	382 aa
Exons	6
GeneCards	S1PR1PROTEIN
Human Protein Atlas	S1PR1PROTEIN
N-linked glycosylation	At Asn-16 and other sites, affects folding and trafficking
Palmitoylation	At cysteine residues near the membrane, affects localization
Phosphorylation	At serine/threonine residues in the C-terminal tail, mediates desensitization
Associated Diseases	blood_brain_barrier, immune cell trafficking
Interactions	STAT3
SciDEX Hypotheses	Sphingosine-1-Phosphate Gradient Disruption
KG Connections	12 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

S1PR1 (Sphingosine-1-Phosphate Receptor 1) Protein

protein · 1897 words

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Pathway Diagram

graph TD
    S1PR1PROTEIN["S1PR1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    S1PR1PROTEIN -->|"implicated_in"| neurodegeneration
    style S1PR1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning S1PR1PROTEIN in their description or question text

No additional research found