gene

STAT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3681Connections

9Hypotheses

12Analyses

50Outgoing

50Incoming

0Experiments

15Debates

Summary

Signal Transducer and Activator of Transcription 3 - key transcription factor in neuroinflammation and neuronal survival

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🧬 Gene Info

Gene Symbol	STAT3
Full Name	Signal Transducer and Activator of Transcription 3
Chromosome	17q21.2
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	92 kDa
Amino Acids	770 aa
Pathways	Akt, Amyloid, Angiogenesis, Apoptosis, Autophagy
UniProt ID	[P40763](https://www.uniprot.org/uniprot/P40763)
Ensembl ID	ENSG00000168610
GeneCards	STAT3
Human Protein Atlas	STAT3
Associated Diseases	acute lung injury, Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Acetyl-CoA, BARICITINIB, Benzo[a]pyrene, curcumin, Curcumin, dimethyl fumarate
Interactions	ABCG2, acetyl-CoA, ACETYL-COA, ACHE, ACSL4, Actin
SciDEX Hypotheses	Spinal Cord Astrocyte Reactivity Convergence Dual Astrocyte-Microglia Phenotype Synchronization
KG Connections	3626 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STAT3["STAT3"] -->|"regulates"| MMP9["MMP9"]
    STAT3["STAT3"] -->|"regulates"| GFAP["GFAP"]
    STAT3["STAT3"] -->|"regulates"| MYC["MYC"]
    STAT3["STAT3"] -->|"regulates"| BCL2["BCL2"]
    STAT3["STAT3"] -->|"interacts"| Cancer["Cancer"]
    STAT3["STAT3"] -->|"interacts"| Als["Als"]
    JAK["JAK"] -->|"activates"| STAT3["STAT3"]
    GP130["GP130"] -->|"activates"| STAT3["STAT3"]
    TSPAN8["TSPAN8"] -->|"interacts"| STAT3["STAT3"]
    TRF33["TRF33"] -.->|"inhibits"| STAT3["STAT3"]
    style STAT3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2075)

Target	Relation	Type	Str
CYTOKINES	activates	gene	1.00
Apoptosis	therapeutic_target	pathway	1.00
TNF-Α	inhibits	gene	1.00
INFLAMMATION	activates	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
AUTOPHAGY	activates	gene	1.00
IL-6	inhibits	gene	1.00
IL-6	activates	entity	1.00
Cancer	regulates	disease	1.00
Tumor	therapeutic_target	disease	1.00
INFLAMMATION	inhibits	gene	1.00
CANCER	therapeutic_target	gene	1.00
Inflammation	therapeutic_target	disease	1.00
CANCER	inhibits	gene	1.00
GENES	activates	gene	1.00
Als	therapeutic_target	disease	1.00
Aging	activates	disease	1.00
CANCER	regulates	disease	1.00
Als	regulates	disease	1.00
Alzheimer	activates	disease	1.00
Nf-Κb	regulates	pathway	1.00
Angiogenesis	activates	pathway	1.00
Autoimmune	activates	disease	1.00
Als	activates	disease	1.00
Inflammation	inhibits	disease	1.00
NEUROINFLAMMATION	activates	gene	1.00
Tumor	activates	disease	1.00
CANCER	activates	disease	1.00
Cancer	activates	disease	1.00
Carcinoma	activates	disease	1.00
Apoptosis	activates	pathway	1.00
AKT	therapeutic_target	gene	1.00
Cancer	inhibits	disease	1.00
Apoptosis	inhibits	pathway	1.00
Inflammation	regulates	disease	1.00
Autophagy	activates	pathway	1.00
Tumor	regulates	disease	1.00
NF-ΚB	associated_with	gene	1.00
Inflammation	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
Neuroinflammation	activates	disease	1.00
Nf-Κb	activates	pathway	1.00
Cancer	therapeutic_target	disease	1.00
Immune Response	activates	pathway	1.00
Als	inhibits	disease	1.00
PI3K	therapeutic_target	gene	1.00
Jak-Stat	activates	pathway	1.00
Tumor	inhibits	disease	1.00
JAK2	activates	gene	1.00
Apoptosis	regulates	pathway	1.00

Incoming (1606)

Source	Relation	Type	Str
APOPTOSIS	activates	gene	1.00
TNF	activates	gene	1.00
APOPTOSIS	targets	gene	1.00
IL-6	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
ds-db4a006ea647	data_in	dataset	1.00
APOPTOSIS	regulates	gene	1.00
ROS	activates	gene	1.00
TNF	inhibits	gene	1.00
CASP3	associated_with	gene	0.98
NEUROINFLAMMATION	associated_with	concept	0.98
LEPTIN	activates	protein	0.95
IPA	inhibits	compound	0.95
PHF2	regulates	enzyme	0.95
IL-6R	activates	protein	0.95
LRWE	downregulates	compound	0.95
FYN	activates	gene	0.95
MN	downregulates	compound	0.95
Polyphyllin B	binds_to	drug	0.95
CHI3L1	binds_to	protein	0.95
CASP3	activates	gene	0.95
isoquercitrin	binds_to	drug	0.95
ILA	inhibits	drug	0.95
Cyclosporine A	upregulates	drug	0.92
leptin signaling	activates	pathway	0.92
BRSK2	activates	protein	0.90
TRIM32	inhibits	protein	0.90
Curcumin	inhibits	drug	0.90
FAK	activates	protein	0.90
PKM2	phosphorylates	protein	0.90
JAK	phosphorylates	protein	0.90
NF-KB	interacts_with	pathway	0.90
NF-KB	associated_with	protein	0.90
JAK	activates	protein	0.90
JAK1	activates	protein	0.90
JAK	associated_with	gene	0.90
SBP	downregulates	drug	0.90
JAK2	activates	protein	0.90
PPP1CB	modifies	protein	0.90
JAK2	phosphorylates	protein	0.90
IL6	interacts_with	protein	0.90
IL6	activates	protein	0.90
ACETYL-COA	activates	gene	0.90
ERK	activates	gene	0.90
TNF	therapeutic_target	gene	0.90
AKT1	targets	gene	0.90
PD-L1	binds_to	protein	0.89
OPN	activates	protein	0.88
SD36	inhibits	drug	0.88
S1PR1	phosphorylates	protein	0.88

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-In	0.618	neurodegeneration	How do perivascular cells specifically r
Astrocytic SPP1 Modulation Through STAT3-Dependent Transcrip	0.551	neuroinflammation	What molecular mechanisms mediate SPP1-i
CNTF-JAK/STAT3 Reprogramming of Trained Microglia to Neuropr	0.547	neuroinflammation	What specific astrocyte-derived factors
Systemic IL-6–STAT3–Hepatic C3 Axis and BBB-Mediated Complem	0.540	neuroinflammation	How does sevoflurane-induced NF-κB activ
Astrocytic SPP1 Modulation via STAT3-Dependent Transcription	0.459	neuroinflammation	What molecular mechanisms mediate SPP1-i

Spinal Cord Astrocyte Reactivity Convergence	0.455	neuroinflammation	Why do clinical manifestations overlap d
RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upre	0.442	neurodegeneration	How do perivascular cells specifically r
STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine	0.347	immunomics	Systemic immune profiling in neurodegene
Dual Astrocyte-Microglia Phenotype Synchronization	0.000	-	Immune atlas neuroinflammation analysis

Mentioning Analyses (12)

Scientific analyses that reference this entity

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.651

Which neural cell types exhibit the most pronounced gene expression alterations

neurodegeneration | 2026-04-11 | 0 hypotheses

Why do clinical manifestations overlap despite distinct underlying etiologies in

neuroinflammation | 2026-04-08 | 7 hypotheses Top: 0.455

What specific astrocyte-derived factors can 'erase' pathological microglial memo

neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.712

What causes IBA1 low/negative microglia in liver disease and how does this affec

neuroinflammation | 2026-04-07 | 7 hypotheses Top: 0.743

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (15)

Multi-agent debates referencing this entity

Debate: Microglial TREM2 downregulation impairs damage-associated response in la

closed · Rounds: 4 · Score: 0.21 · 2026-04-27

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

The abstract indicates SPP1 upregulation occurs in perivascular macrophages and

closed · Rounds: 4 · Score: 0.67 · 2026-04-22

The abstract describes IBA1 low/negative microglia in individuals with liver dis

closed · Rounds: 4 · Score: 0.76 · 2026-04-21

The astrocyte-mediated hypothesis proposes memory erasure but provides no molecu

closed · Rounds: 4 · Score: 0.65 · 2026-04-21

The debate generated therapeutic hypotheses targeting different cell types but n

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

The abstract describes astrocyte phenotypic heterogeneity (A1/A2) but doesn't ex

closed · Rounds: 4 · Score: 0.66 · 2026-04-15

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

closed · Rounds: 4 · Score: 0.69 · 2026-04-12

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

closed · Rounds: 7 · Score: 0.91 · 2026-04-10

The abstract notes that clinical presentations overlap across different myelopat

closed · Rounds: 4 · Score: 0.86 · 2026-04-09

Related Research

Hypotheses and analyses mentioning STAT3 in their description or question text

Spinal Cord Astrocyte Reactivity Convergence

Score: 0.455 · neuroinflammation · 2026-04-27

Inflammatory myelopathies converge through activation of shared astrocyte reactivity program controlled by JAK/STAT3 sig

RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivasc

Score: 0.442 · neurodegeneration · 2026-04-22

## Mechanistic Overview RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivascular Fibroblasts

STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine Memory

Score: 0.347 · immunomics · 2026-04-25

STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine Memory

Dual Astrocyte-Microglia Phenotype Synchronization

Score: 0.000 · unknown disease · 2026-04-28

Coordinated modulation of A2 astrocyte and beneficial DAM states through shared signaling pathways Debate provenance: d

STAT3

Understanding Entity Pages

Summary

Wiki Pages (3)

STAT3 Gene

STAT3 (Redirect)

STAT3 Protein

Pathway Diagram

Outgoing (2075)

Incoming (1606)

Targeting Hypotheses (9)

Mentioning Analyses (12)

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

Which neural cell types exhibit the most pronounced gene expression alterations

Why do clinical manifestations overlap despite distinct underlying etiologies in

What specific astrocyte-derived factors can 'erase' pathological microglial memo

What causes IBA1 low/negative microglia in liver disease and how does this affec

How do perivascular cells specifically recognize and respond to amyloid-β to upr

SEA-AD Single-Cell Analysis: Cell-Type Vulnerability in Alzheimer's Disease

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

Senolytic therapy for age-related neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Experiments (0)

Related Papers (0)

Debates (15)

Debate: Microglial TREM2 downregulation impairs damage-associated response in la

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

The abstract indicates SPP1 upregulation occurs in perivascular macrophages and

The abstract describes IBA1 low/negative microglia in individuals with liver dis

The astrocyte-mediated hypothesis proposes memory erasure but provides no molecu

The debate generated therapeutic hypotheses targeting different cell types but n

The abstract describes astrocyte phenotypic heterogeneity (A1/A2) but doesn't ex

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

The abstract notes that clinical presentations overlap across different myelopat

Related Research

Spinal Cord Astrocyte Reactivity Convergence

RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivasc

STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine Memory

Dual Astrocyte-Microglia Phenotype Synchronization