Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STAT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Signal Transducer and Activator of Transcription 3 - key transcription factor in neuroinflammation and neuronal survival
| Gene Symbol | STAT3 |
| Full Name | Signal Transducer and Activator of Transcription 3 |
| Chromosome | 17q21.2 |
| Protein Type | Transcription Factor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 92 kDa |
| Amino Acids | 770 aa |
| Pathways | Akt, Amyloid, Angiogenesis, Apoptosis, Autophagy |
| UniProt ID | [P40763](https://www.uniprot.org/uniprot/P40763) |
| Ensembl ID | ENSG00000168610 |
| GeneCards | STAT3 |
| Human Protein Atlas | STAT3 |
| Associated Diseases | ASTROGLIOSIS, Aging, Als, Alzheimer, Alzheimer'S Disease |
| Known Drugs/Compounds | BARICITINIB, RAPAMYCIN, hyperforin, donepezil, STAT3 inhibitors, WP1066 |
| Interactions | IFNG, LC3, RPTOR, RB1, EIF2AK3, RIPK1 |
| KG Connections | 3571 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
STAT3["STAT3"] -->|"regulates"| MMP9["MMP9"]
STAT3["STAT3"] -->|"regulates"| GFAP["GFAP"]
STAT3["STAT3"] -->|"regulates"| MYC["MYC"]
STAT3["STAT3"] -->|"regulates"| BCL2["BCL2"]
STAT3["STAT3"] -->|"interacts"| Cancer["Cancer"]
STAT3["STAT3"] -->|"interacts"| Als["Als"]
JAK["JAK"] -->|"activates"| STAT3["STAT3"]
GP130["GP130"] -->|"activates"| STAT3["STAT3"]
TSPAN8["TSPAN8"] -->|"interacts"| STAT3["STAT3"]
TRF33["TRF33"] -.->|"inhibits"| STAT3["STAT3"]
style STAT3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| PI3K | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| JAK2 | activates | gene | 1.00 |
| CANCER | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Jak-Stat | activates | pathway | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Nf-Κb | regulates | pathway | 1.00 |
| Als | inhibits | disease | 1.00 |
| Angiogenesis | activates | pathway | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| NF-ΚB | associated_with | gene | 1.00 |
| CANCER | regulates | disease | 1.00 |
| IL-6 | activates | entity | 1.00 |
| IL-6 | inhibits | gene | 1.00 |
| TNF-Α | inhibits | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| Autoimmune | activates | disease | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TNF | activates | gene | 1.00 |
| IL-6 | associated_with | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | disease | 1.00 |
| ds-db4a006ea647 | data_in | dataset | 1.00 |
| TNF | inhibits | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| CASP3 | associated_with | gene | 0.98 |
| NEUROINFLAMMATION | associated_with | concept | 0.98 |
| FYN | activates | gene | 0.95 |
| Polyphyllin B | binds_to | drug | 0.95 |
| isoquercitrin | binds_to | drug | 0.95 |
| ILA | inhibits | drug | 0.95 |
| CHI3L1 | binds_to | protein | 0.95 |
| CASP3 | activates | gene | 0.95 |
| PHF2 | regulates | enzyme | 0.95 |
| MN | downregulates | compound | 0.95 |
| IPA | inhibits | compound | 0.95 |
| LRWE | downregulates | compound | 0.95 |
| IL-6R | activates | protein | 0.95 |
| LEPTIN | activates | protein | 0.95 |
| leptin signaling | activates | pathway | 0.92 |
| Cyclosporine A | upregulates | drug | 0.92 |
| IL6 | activates | protein | 0.90 |
| JAK1 | activates | protein | 0.90 |
| JAK2 | phosphorylates | protein | 0.90 |
| PPP1CB | modifies | protein | 0.90 |
| JAK2 | activates | protein | 0.90 |
| TRIM32 | inhibits | protein | 0.90 |
| FAK | activates | protein | 0.90 |
| Curcumin | inhibits | drug | 0.90 |
| Curcumin | suppresses | drug | 0.90 |
| IL6 | interacts_with | protein | 0.90 |
| SBP | downregulates | drug | 0.90 |
| JAK | activates | protein | 0.90 |
| BRSK2 | activates | protein | 0.90 |
| JAK | associated_with | gene | 0.90 |
| ACETYL-COA | activates | gene | 0.90 |
| NF-KB | associated_with | protein | 0.90 |
| NF-KB | interacts_with | pathway | 0.90 |
| PKM2 | phosphorylates | protein | 0.90 |
| JAK | phosphorylates | protein | 0.90 |
| TNF | therapeutic_target | gene | 0.90 |
| AKT1 | therapeutic_target | gene | 0.90 |
| ERK | activates | gene | 0.90 |
| PD-L1 | binds_to | protein | 0.89 |
| SD36 | inhibits | drug | 0.88 |
| OPN | activates | protein | 0.88 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.521
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.507
neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||