gene

SCN3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCN3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for SCN3A Gene

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	SCN3A
Aliases	Sodium Voltage-Gated Channel Alpha Subunit 3
Protein Type	Gene
Function	SCN3A encodes Nav1.3, a voltage-gated sodium channel alpha subunit that mediates the inward sodium current (I_Na) essential for action potential generation and propagation.
Primary Expression	the central nervous system during development
Molecular Weight	260 kDa
GeneCards	SCN3A
Human Protein Atlas	SCN3A
Channel Type	Voltage-gated sodium channel (Nav1.3)
Primary Structure	Large transmembrane protein with 4 repeat domains (I-IV), each containing 6 transmembrane segments (S1-S6)
Gating	Rapid activation and inactivation kinetics
Expression Pattern	High in embryonic and early postnatal brain, upregulated in injured neurons and pathological conditions
Brain	Higher expression during development, persists in thalamus, cortex, and hippocampus
Spinal Cord	Dorsal horn neurons involved in pain transmission
Peripheral Nervous System	Limited expression in adult sensory neurons
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SCN3A Gene

gene · 841 words

→

SCN3A Protein (Sodium Voltage-Gated Channel Alpha Subunit 3)

protein · 672 words

→

Pathway Diagram

graph TD
    SCN3A["SCN3A"]
    neurodegeneration["neurodegeneration"]
    SCN3A -->|"implicated_in"| neurodegeneration
    style SCN3A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SCN3A in their description or question text

No additional research found