gene

SCO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	SCO1
Full Name	Cytochrome c Oxidase Assembly Factor SCO1
Function	is a mitochondrial protein essential for the assembly and function of Cytochrome c Oxidase (Complex IV), the terminal enzyme of the electron transport chain.
Amino Acids	30 aa
Ensembl ID	ENSG00000120265
GeneCards	SCO1
Human Protein Atlas	SCO1
Copper-binding site	Conserved Cys-Gly-Gly-Cys motif that binds Cu(I)
Dimerization interface	SCO1 functions as a homodimer
Interaction surfaces	Sites for binding to cytochrome c oxidase subunits
CuA site	Located on subunit II, receives copper from SCO1
CuB site	Located on subunit I, receives copper from SCO2 (in some organisms)
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SCO1 — Cytochrome c Oxidase Assembly Factor SCO1

gene · 3037 words

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ESCO1 - Establishment of Sister Chromatid Cohesion N-Acetyltransferase 1

gene · 643 words

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Pathway Diagram

graph TD
    SCO1["SCO1"]
    neurodegeneration["neurodegeneration"]
    SCO1 -->|"implicated_in"| neurodegeneration
    style SCO1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SCO1 in their description or question text

No additional research found