gene

SEC61A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SEC61A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for SEC61A1 - Sec61 Translocon Alpha 1

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🧬 Gene Info

Gene Symbol	SEC61A1
Full Name	Sec61 Translocon Alpha 1
Aliases	Page for SEC61A1, Page for SEC61A1 Protein
Chromosome	3q21.3
Function	Co-translational Translocation: As the ribosome synthesizes a nascent polypeptide with an ER signal sequence, the Sec61 channel allows the growing chain to pass directly into the ER lumen [2]
Primary Expression	Cerebral cortex, Hippocampus, Basal ganglia, Spinal cord
Molecular Weight	52 kDa
UniProt ID	P61019
NCBI Gene ID	29927
Ensembl ID	ENSG00000058262
OMIM	609163
GeneCards	SEC61A1
Human Protein Atlas	SEC61A1
Symbol [@gorlich2000] SEC61A1 [@rabi2020] [@hegde2009] Full Name	SEC61 Translocon Alpha 1 Subunit
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SEC61A1 — AlphaFold P61019 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SEC61A1["SEC61A1"]
    neurodegeneration["neurodegeneration"]
    SEC61A1 -->|"implicated_in"| neurodegeneration
    style SEC61A1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SEC61A1

Understanding Entity Pages

Summary

Wiki Pages (5)

SEC61A1 - Sec61 Translocon Alpha 1

SEC61G Gene

SEC61A1 Protein - Sec61 Translocon Alpha 1

Proteins