Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SEC61A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SEC61A1 |
| Full Name | Sec61 Translocon Alpha 1 |
| Aliases | Page for SEC61A1, Page for SEC61A1 Protein |
| Chromosome | 3q21.3 |
| Function | Co-translational Translocation: As the ribosome synthesizes a nascent polypeptide with an ER signal sequence, the Sec61 channel allows the growing chain to pass directly into the ER lumen [2] |
| Primary Expression | Cerebral cortex, Hippocampus, Basal ganglia, Spinal cord |
| Molecular Weight | 52 kDa |
| UniProt ID | P61019 |
| NCBI Gene ID | 29927 |
| Ensembl ID | ENSG00000058262 |
| OMIM | 609163 |
| GeneCards | SEC61A1 |
| Human Protein Atlas | SEC61A1 |
| High Protein Synthesis | Neurons have extremely high rates of protein synthesis, particularly at synapses |
| Secretory Pathway Traffic | Synaptic proteins, receptors, and neurotransmitters require proper ER processing |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SEC61A1["SEC61A1"]
neurodegeneration["neurodegeneration"]
SEC61A1 -->|"implicated_in"| neurodegeneration
style SEC61A1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SEC61A1 in their description or question text
No additional research found