Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SEM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Gene Symbol | SEM1 |
| Function | SEM1 is a component of the 19S regulatory particle (PA700) of the 26S proteasome. The protein: |
| Subcellular Localization | to both nucleus and cytoplasm, with enrichment at the proteasome |
| GeneCards | SEM1 |
| Human Protein Atlas | SEM1 |
| Amyotrophic lateral sclerosis | Rare variants identified in ALS patients |
| Frontotemporal dementia | Altered expression in FTD brain tissue |
| Haploinsufficiency models | Reduced SEM1 leads to proteasome impairment |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SEM1["SEM1"]
neurodegeneration["neurodegeneration"]
SEM1 -->|"implicated_in"| neurodegeneration
style SEM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SEM1 in their description or question text
No additional research found