Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SEPTIN5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GTP-binding protein involved in synaptic function, cytokinesis, and neurodegenerative disease pathogenesis
No AI portrait yet
| Gene Symbol | SEPTIN5 |
| Full Name | Septin 5 |
| Chromosome | 22q11.21 |
| Function | encodes a member of the septin family of GTP-binding proteins essential for cytoskeleton organization, cell division, and membrane dynamics. |
| Primary Expression | the nervous system and is particularly important for synaptic vesicle organization, neurotransmitter release, and neuronal survival |
| Amino Acids | 367 aa |
| UniProt ID | Q9NSC5 |
| NCBI Gene ID | 54148 |
| Ensembl ID | ENSG00000100338 |
| GeneCards | SEPTIN5 |
| Human Protein Atlas | SEPTIN5 |
| Septin unique element (SUE) | a conserved 30-amino acid insert unique to septins |
| Cerebral cortex | Layer V pyramidal neurons (corticospinal motor neurons) |
| Hippocampus | CA3 pyramidal cells and dentate gyrus granule cells |
| Cerebellum | Purkinje cells (major inhibitory output neurons) |
| Associated Diseases | Parkinson's Disease, Alzheimer's Disease, Lewy Body Dementia |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SEPTIN5["SEPTIN5"]
neurodegeneration["neurodegeneration"]
SEPTIN5 -->|"implicated_in"| neurodegeneration
style SEPTIN5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SEPTIN5 in their description or question text
No additional research found