gene

SEPTIN8

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SEPTIN8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

SEPTIN8 Gene

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🧬 Gene Info

Gene Symbol	Septin 8
Chromosome	5q31.1
Function	is a member of the septin family of GTP-binding proteins that play critical roles in cytoskeletal organization, membrane dynamics, and synaptic function.
Primary Expression	neurons and is enriched at synaptic terminals where it participates in synaptic vesicle trafficking and neurotransmitter release[
UniProt ID	Q9UQD8
NCBI Gene ID	23176
Ensembl ID	ENSG00000141504
OMIM	607410
N-terminal polybasic region	Involved in membrane association through phosphatidylinositol phosphate binding
C-terminal coiled-coil domain	Mediates interaction with other septin subunits and binding partners
Cerebral cortex	Layer 5 pyramidal neurons show robust SEPTIN8 expression
Basal ganglia	Striatal medium spiny neurons
Cerebellum	Purkinje cells
Substantia nigra	Dopaminergic neurons
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SEPTIN8 — AlphaFold Q9UQD8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SEPTIN8 Gene

gene · 1493 words

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Pathway Diagram

graph TD
    SEPTIN8["SEPTIN8"]
    neurodegeneration["neurodegeneration"]
    SEPTIN8 -->|"implicated_in"| neurodegeneration
    style SEPTIN8 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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