SETDB1

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolSETDB1
NameSET domain bifurcated histone lysine methyltransferase 1
Typeprotein-coding
Sourcemygene

Summary

This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011].

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