gene

SGSM1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SGSM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Small G Protein Signaling Modulator 1 - RAB GTPase regulator in neurodegeneration

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🧬 Gene Info

Gene Symbol	SGSM1
Aliases	Small G Protein Signaling Modulator 1
Chromosome	17p13.1
Function	RAB GTPases cycle between an active GTP-bound state and an inactive GDP-bound state, and this cycling is precisely controlled by two families of regulatory proteins: guanine nucleotide exchange factor
Molecular Weight	102 kDa
Amino Acids	910 aa
Ensembl ID	ENSG00000156469
GeneCards	SGSM1
Human Protein Atlas	SGSM1
Autophagic Flux	Through regulation of RAB proteins involved in autophagosome formation and maturation, SGSM1 influences the autophagy-lysosome pathway that is critical for neuronal homeostasis [6].
Synaptic Vesicle Cycling	RAB3 and RAB27 family members regulate synaptic vesicle exocytosis and endocytosis. SGSM1 helps maintain the precise timing of vesicle cycling required for continuous neurotransmission [7].
Receptor Trafficking	Regulation of RAB5 and RAB11 controls neurotrophin receptor (TrkB) and glutamate receptor (AMPA, NMDA) trafficking, affecting synaptic plasticity and neuronal survival [8].
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SGSM1

gene · 1791 words

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Pathway Diagram

graph TD
    SGSM1["SGSM1"]
    neurodegeneration["neurodegeneration"]
    SGSM1 -->|"implicated_in"| neurodegeneration
    style SGSM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Experiments (0)

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Related Papers (0)

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Related Research

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