SIGLEC1

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolSIGLEC1
Namesialic acid binding Ig like lectin 1
Typeprotein-coding
Sourcemygene

Summary

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection. [provided by

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