gene 1,483 words KG: SIGLEC1 2026-03-27
kind:genesection:genesstate:published
Contents

SIGLEC1 Gene

🧬 Gene Info
Gene SymbolSIGLEC1
Full NameSialic Acid-Binding Ig-Like Lectin 1
Chromosome20p13
Protein TypeReceptor
FunctionSialic Acid Recognition: Binds to sialylated glycans on host cells and pathogens
Molecular Weight185 kDa
Amino Acids1644 aa
UniProt ID[Q9PMN3](https://www.uniprot.org/uniprot/Q9PMN3)
Ensembl IDENSG00000105550
OMIM600738
GeneCardsSIGLEC1
Human Protein AtlasSIGLEC1
N-terminal V-type Ig domainContains the sialic acid-binding site
C2-type Ig domains (16 repeats)Form the stalk region
Mucin-like regionProvides extended structure
Associated Diseasesneurodegeneration
KG Connections46 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Knowledge Graph (12 edges)

SIGLEC1 therapeutic_target SPR
SIGLEC1 therapeutic_target APOE
SIGLEC1 associated_with MAPK10
SIGLEC1 co_discussed SORL1
SIGLEC1 co_discussed SPI1
SIGLEC1 co_discussed TAU
SIGLEC1 co_discussed TMEM106B
SIGLEC1 co_discussed TREM2
SIGLEC1 therapeutic_target Diabetes
SIGLEC1 therapeutic_target Als