Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SIGLEC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SIGLEC3 (CD33) is a sialic acid-binding immunoglobulin-like lectin expressed primarily on microglia. It modulates neuroinflammation and phagocytosis in the brain, with genetic variants influencing Alzheimer's disease risk.
| Gene Symbol | SIGLEC3 |
| Chromosome | 19q13.41 |
| Function | is a member of the siglec (sialic acid-binding immunoglobulin-like lectin) family of cell surface receptors[@crocker2012]. |
| Amino Acids | 382 aa |
| Exons | 7 |
| Ensembl ID | ENSG00000105383 |
| GeneCards | SIGLEC3 |
| Human Protein Atlas | SIGLEC3 |
| Associated Diseases | ALS, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, Aging |
| Known Drugs/Compounds | Stem Cell Therapy |
| Interactions | OVERVIEW, PSEN1, BCL2, APP, DAP12, APOE |
| KG Connections | 708 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SIGLEC3["SIGLEC3"]
neurodegeneration["neurodegeneration"]
SIGLEC3 -->|"implicated_in"| neurodegeneration
style SIGLEC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||