gene 1,592 words KG: SIGLEC3 2026-03-27
kind:genesection:genesstate:published
Contents

SIGLEC3 Gene (CD33)

🧬 Gene Info
Gene SymbolSIGLEC3
Chromosome19q13.41
Functionis a member of the siglec (sialic acid-binding immunoglobulin-like lectin) family of cell surface receptors[@crocker2012].
Amino Acids382 aa
Exons7
Ensembl IDENSG00000105383
GeneCardsSIGLEC3
Human Protein AtlasSIGLEC3
Associated DiseasesALS, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, Aging
Known Drugs/CompoundsStem Cell Therapy
InteractionsOVERVIEW, PSEN1, BCL2, APP, DAP12, APOE
KG Connections708 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49

Related Analyses (6)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in