Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SIRT1 activity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer disease progression | biomarker_for | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NAD+ depletion | inhibits | process | 0.90 |
| NAD+/NADH ratio | modulates | biomarker | 0.90 |
| NAD+ decline | reduces | process | 0.90 |
| NAD+ decline | inhibits | process | 0.90 |
| NAD+ decline | causes | process | 0.90 |
| NAD+ | regulates | metabolite | 0.90 |
| Nad+ | regulates | drug | 0.90 |
| NAD+ | modulates | metabolite | 0.90 |
| Nad+ Precursors | associated_with | drug | 0.70 |
| AMPK | activates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 0 hypotheses
immunology | 2026-04-08 | 1 hypotheses Top: 0.380
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.770
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.779
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.46 · 2026-04-27
closed · Rounds: 4 · Score: 0.46 · 2026-04-27
closed · Rounds: 4 · Score: 0.67 · 2026-04-22
closed · Rounds: 4 · Score: 0.79 · 2026-04-22
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.95 · 2026-04-10
closed · Rounds: 4 · Score: 0.93 · 2026-04-10
Hypotheses and analyses mentioning SIRT1 activity in their description or question text
No additional research found