Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NAD+: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NAD+ |
| Summary | Cross-referencing NAD+ metabolic approaches with investment signals to identify high-conviction bioenergetics therapeutics for neurodegenerative diseases |
| Key Genes/Proteins | SIRT1, CX43, PARP1, AMPK |
| Related Pathways | Cellular Processes |
| Linked Hypotheses | 6 hypotheses |
Knowledge base pages for this entity
graph TD
NAD_["NAD+"]
NAD_ -.protects against.-> Blood_Brain_Barrier_Damage["Blood-Brain Barrier Damage"]
NAD_ -->|"involved_in"| Purinergic_Signaling["Purinergic Signaling"]
NAD_ -->|"involved_in"| Redox_Metabolism["Redox Metabolism"]
NAD_ -->|"involved_in"| DNA_Repair["DNA Repair"]
NAD_ -->|"regulates"| SIRTUINS["SIRTUINS"]
NAD_ -->|"regulates"| PARP["PARP"]
NAD_ -->|"regulates"| CD38["CD38"]
NAD_ -->|"involved_in"| Energy_Metabolism["Energy Metabolism"]
Nmn["Nmn"] -->|"contributes to"| NAD_
NAMPT["NAMPT"] -->|"modulates"| NAD_
Aging["Aging"] -->|"downregulates"| NAD_
NMN["NMN"] -->|"involved_in"| NAD_
AMPK["AMPK"] -->|"activates"| NAD_
SIRT["SIRT"] -->|"substrate_of"| NAD_
PARP -->|"downregulates"| NAD_| Target | Relation | Type | Str |
|---|---|---|---|
| BLOOD-BRAIN BARRIER DAMAGE | protects_against | entity | 0.90 |
| SIRT1 | activates | protein | 0.90 |
| Cellular Processes | associated_with | biological_process | 0.80 |
| inflammation | modulates | process | 0.70 |
| SIRT1 | regulates | entity | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D | 0.614 | neurodegeneration | What is the molecular mechanism by which |
| Senescence-Activated NAD+ Depletion Rescue | 0.604 | neurodegeneration | Senolytic therapy for age-related neurod |
| Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Ove | 0.592 | neurodegeneration | Epigenetic reprogramming in aging neuron |
| Mitochondrial NAD+ Salvage Enhancement | 0.426 | neurodegeneration | Gene expression changes in aging mouse b |
| SIRT6-NAD+ Axis Enhancement Therapy | 0.395 | neurodegeneration | Epigenetic clocks and biological aging i |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and De [PMID:38580317] | Velma GR, Krider IS, Alves ETM, Courey J | J Med Chem | 2024 | 1 |
| SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation re [PMID:36593966] | Li B, Xin Z, Gao S, Li Y, Guo S, Fu Y, X | Theranostics | 2023 | 1 |
| Assessing the Status of Mandatory Tuberculosis Case Notification among Private P [PMID:35068738] | Duggal K, Elsy M, Majella MG, Akkilagunt | Indian J Community Med | 2021 | 1 |
| Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic [PMID:33888596] | Yoshino M, Yoshino J, Kayser BD, Patti G | Science | 2021 | 1 |
| NAD(+) metabolism, stemness, the immune response, and cancer. [PMID:33384409] | Navas LE, Carnero A | Signal Transduct Target Ther | 2021 | 1 |
| Protocol for the Bottom-Up Proteomic Analysis of Mouse Spleen. [PMID:33377090] | Dowling P, Gargan S, Zweyer M, Henry M, | STAR Protoc | 2020 | 1 |
| Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity [PMID:30193097] | Latorre-Muro P, Baeza J, Armstrong EA, H | Mol Cell | 2018 | 1 |
| NAD metabolism fuels human and mouse intestinal inflammation. [PMID:28877980] | Gerner RR, Klepsch V, Macheiner S, Arnha | Gut | 2018 | 1 |
| The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcin [PMID:28329682] | Nargund AM, Pham CG, Dong Y, Wang PI, Os | Cell Rep | 2017 | 1 |
| Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype [PMID:26686024] | Wiley CD, Velarde MC, Lecot P, Liu S, Sa | Cell Metab | 2016 | 1 |
| NAD+ and sirtuins in aging and disease. [PMID:24786309] | Imai S, Guarente L | Trends Cell Biol | 2014 | 1 |
| Mitochondrial NAD(+)-mediated mitophagy alleviates type I interferon response to [PMID:41231107] | Lan T, Shang D, Lin L, Wang H, Zou J et | Autophagy | 2026 | 0 |
| cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960] | Fazal F, Dar NJ, Ahamad S, Khan S, Bano | Mol Aspects Med | 2026 | 0 |
| Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397] | Lu C, Wang W, Fu YX | Nat Rev Cancer | 2026 | 0 |
| CircZBTB44-Encoded Peptide ZBTB44-342aa Alleviates Aortic Valve Calcification Vi [PMID:41487094] | Hu D, Lin Y, Huang H, Xian G, Chen Y et | Circ Res | 2026 | 0 |
| Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200] | Li D, Cui G, Yang K, Lu C, Jiang Y et al | Nat Cell Biol | 2026 | 0 |
| cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413] | Solomon J, Mandal S, Aran KR | Gene | 2026 | 0 |
| Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867] | Li L, Ye Q, Ma J, Wang Z, Liu T et al. | Cancer Cell | 2026 | 0 |
| Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081] | Qin H, Yang L, Du J, Xu X, Chen Z et al. | Int Immunopharmacol | 2026 | 0 |
| EsxN drives ISG15-mediated dsDNA release to activate cGAS-STING signaling and pr [PMID:41738749] | Zhang Q, Abudukadier A, Chen H, Xiong L, | Microbiol Spectr | 2026 | 0 |