protein

SLACKCHANNEL

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SLACKCHANNEL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	SLACKCHANNEL
Protein Type	Channel
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the brain, particularly in the cortex, hippocampus, thalamus, and basal ganglia, where it regulates neuronal firing patterns and protects against sodi
Subcellular Localization	</b></td><td>Plasma membrane, Neuronal membranes, Dendrites</td></tr>
Molecular Weight	110 kDa
GeneCards	SLACKCHANNEL
Human Protein Atlas	SLACKCHANNEL
Transmembrane domains	6 TM segments (S1-S6) typical of voltage-gated potassium channels
Voltage sensor	S4 segment contains positively charged residues for voltage sensing
Pore region	Hinged-lid mechanism for K+ selectivity and conductance
Cytoplasmic C-terminal tail	Contains the unique sodium-sensing region
Slo domain	Characteristic of Slo family channels, involved in ligand sensing
Sodium-activated K+ current	Provides outward K+ current activated by intracellular Na+ accumulation during repetitive firing
Repolarization assistance	Helps repolarize neurons after action potentials, especially during high-frequency firing
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Slack Channel Protein (KCNT1)

protein · 898 words

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Pathway Diagram

graph TD
    SLACKCHANNEL["SLACKCHANNEL"]
    neurodegeneration["neurodegeneration"]
    SLACKCHANNEL -->|"implicated_in"| neurodegeneration
    style SLACKCHANNEL fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Related Research

Hypotheses and analyses mentioning SLACKCHANNEL in their description or question text

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