gene

SLC24A1

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This page aggregates everything SciDEX knows about SLC24A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for SLC24A1 — Solute Carrier Family 2 Member 4A1 (SLC24A1)

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🧬 Gene Info

Gene Symbol	SLC24A1
Full Name	Sodium/Calcium Exchanger 1 (NCKX1)
Function	This unique coupling allows for efficient calcium extrusion against steep concentration gradients, making it crucial for
Primary Expression	rod and cone photoreceptors where it mediates Ca2+ extrusion during light adaptation [2](https://pubmed
Amino Acids	501 aa
UniProt ID	O60739
Ensembl ID	ENSG00000100767
GeneCards	SLC24A1
Human Protein Atlas	SLC24A1
Photoreceptor function	NCKX1 is highly expressed in rod and cone photoreceptors where it mediates Ca2+ extrusion during light adaptation 2
Neuronal calcium regulation	Controls cytosolic Ca2+ levels in various neuronal populations
Synaptic plasticity	Calcium extrusion supports long-term potentiation and memory formation
Calcium dysregulation hypothesis	Aβ oligomers cause pathological Ca2+ influx through various channels
NCKX1 downregulation	Studies suggest reduced NCKX1 expression in AD brain 3
Therapeutic potential	Enhancing NCKX1 function could improve Ca2+ extrusion
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SLC24A1 — AlphaFold O60739 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC24A1 — Solute Carrier Family 2 Member 4A1 (SLC24A1)

gene · 575 words

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Pathway Diagram

graph TD
    SLC24A1["SLC24A1"]
    neurodegeneration["neurodegeneration"]
    SLC24A1 -->|"implicated_in"| neurodegeneration
    style SLC24A1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning SLC24A1 in their description or question text

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