Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC4A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SLC4A1 |
| Full Name | Solute Carrier Family 4 Member 1 (Anion Exchanger 1) |
| Aliases | Anion Exchanger 1 |
| Chromosome | 17q21.31 |
| Function | is a membrane protein that facilitates the exchange of chloride (Cl⁻) and bicarbonate (HCO₃⁻) ions across cell membranes[@alper2001]. |
| Primary Expression | erythrocytes (red blood cells) and the kidney[@cordat2020], where it plays critical roles in ion homeostasis and cellular function |
| Molecular Weight | 95 kDa |
| Amino Acids | 911 aa |
| Exons | 26 |
| GeneCards | SLC4A1 |
| Human Protein Atlas | SLC4A1 |
| Brain | Low but detectable expression in certain neuronal populations[@hata1993] |
| Heart | Moderate expression in cardiac myocytes |
| Lung | Expression in alveolar epithelial cells |
| Gastrointestinal tract | Intestinal epithelial cells |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SLC4A1["SLC4A1"]
neurodegeneration["neurodegeneration"]
SLC4A1 -->|"implicated_in"| neurodegeneration
style SLC4A1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SLC4A1 in their description or question text
No additional research found