Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC4A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SLC4A2 |
| Chromosome | 7q34 |
| Protein Type | Anion antiporter (Cl⁻/HCO₃⁻ exchanger) |
| Function | is a critical membrane transport protein that mediates the electroneutral exchange of chloride (Cl⁻) and bicarbonate (HCO₃⁻) ions across cell membranes. |
| Primary Expression | neurons, astrocytes, and other supporting cells, where it contributes to the precise regulation of intracellular and extracellular pH |
| Molecular Weight | 110 kDa |
| Amino Acids | 1035 aa |
| GeneCards | SLC4A2 |
| Human Protein Atlas | SLC4A2 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SLC4A2["SLC4A2"]
neurodegeneration["neurodegeneration"]
SLC4A2 -->|"implicated_in"| neurodegeneration
style SLC4A2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SLC4A2 in their description or question text
No additional research found