Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC6A13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SLC6A13 |
| Full Name | Solute Carrier Family 6 Member 13 (GABA Transporter 2, GAT2) |
| Chromosome | 12p13.33 |
| Function | encodes a membrane transport protein responsible for the uptake of gamma-aminobutyric acid (GABA) from the extracellular space. |
| Primary Expression | astrocytes but at lower levels than GAT3 (SLC6A11) [5]: |
| Molecular Weight | ~63 kDa |
| Amino Acids | 572 aa |
| UniProt ID | Q9NPD8 |
| NCBI Gene ID | 6404 |
| Ensembl ID | ENSG00000110851 |
| OMIM | 607469 |
| GeneCards | SLC6A13 |
| Human Protein Atlas | SLC6A13 |
| Protein Length | 572 amino acids |
| GABA | Highest |
| Associated Diseases | Carotid Paragangliomas, Metabolite Levels, Neurological Disorders |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
SLC6A13(["SLC6A13"])
GABA["GABA"]
Metabolite_Levels("Metabolite Levels")
GAT1(["GAT1"])
Neurological_Disorders["Neurological Disorders"]
Carotid_Paragangliomas["Carotid Paragangliomas"]
neurodegeneration["neurodegeneration"]
SLC6A13 -->|"associated with"| GABA
SLC6A13 -->|"associated with"| Metabolite_Levels
SLC6A13 -->|"associated with"| GAT1
SLC6A13 -->|"implicated in"| Neurological_Disorders
SLC6A13 -->|"associated with"| Carotid_Paragangliomas
SLC6A13 -->|"implicated in"| neurodegeneration
style SLC6A13 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Metabolite Levels | associated_with | phenotype | 0.80 |
| GABA | associated_with | entity | 0.80 |
| GAT1 | associated_with | gene | 0.70 |
| Neurological Disorders | implicated_in | disease | 0.60 |
| Carotid Paragangliomas | associated_with | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||