gene

GABA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1323Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

GABA is a gene implicated in neurodegeneration research. Key relationships include: co discussed, activates, associated with. Associated with ALS, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE. Connected to 67 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GABA
Chromosome	12p12.3
Function	is a hallmark of neurodegeneration.
Primary Expression	hippocampus, cortex, cerebellum, thalamus, hypothalamus
Amino Acids	602 aa
Exons	14
Pathways	GABAergic Signaling
GeneCards	GABA
Human Protein Atlas	GABA
GABA_A receptors	Ligand-gated chloride channels mediating fast inhibitory signaling
GABA_B receptors	G-protein coupled receptors mediating slow, prolonged inhibition
Associated Diseases	ALS, ALZHEIMER'S DISEASE, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	ATG, MTOR, RB1CC1, JNK, MAVS, HUNTINGTON
KG Connections	1323 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

GABA (Gamma-Aminobutyric Acid) - Neurodegenerative Disease Biomarker

biomarker · 1507 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    GABA["<b>GABA</b>"]
    JNK["JNK"]
    GABA -->|"co discussed"| JNK
    LC3["LC3"]
    GABA -->|"co discussed"| LC3
    LRRK2["LRRK2"]
    GABA -->|"co discussed"| LRRK2
    MTOR["MTOR"]
    GABA -->|"co discussed"| MTOR
    ULK1["ULK1"]
    GABA -->|"co discussed"| ULK1
    HISTONE["HISTONE"]
    GABA -->|"co discussed"| HISTONE
    ISCHEMIA["ISCHEMIA"]
    GABA -->|"co discussed"| ISCHEMIA
    HTT["HTT"]
    GABA -->|"co discussed"| HTT
    MITOCHONDRIA["MITOCHONDRIA"]
    GABA -->|"co discussed"| MITOCHONDRIA
    MITOPHAGY["MITOPHAGY"]
    GABA -->|"co discussed"| MITOPHAGY
    PINK1["PINK1"]
    GABA -->|"co discussed"| PINK1
    HYPOTHALAMUS["HYPOTHALAMUS"]
    GABA -->|"co discussed"| HYPOTHALAMUS
    CRH["CRH"]
    CRH -->|"regulates"| GABA
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"co discussed"| GABA
    EPILEPSY["EPILEPSY"]
    EPILEPSY -->|"co discussed"| GABA
    APP["APP"]
    APP -->|"co discussed"| GABA
    BECN1["BECN1"]
    BECN1 -->|"co discussed"| GABA
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"co discussed"| GABA
    FRONTOTEMPORAL["FRONTOTEMPORAL"]
    FRONTOTEMPORAL -->|"co discussed"| GABA
    FTD["FTD"]
    FTD -->|"co discussed"| GABA
    CIRCADIAN["CIRCADIAN"]
    CIRCADIAN -->|"co discussed"| GABA
    DOPAMINERGIC["DOPAMINERGIC"]
    DOPAMINERGIC -->|"co discussed"| GABA
    DEPRESSION["DEPRESSION"]
    DEPRESSION -->|"co discussed"| GABA
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"co discussed"| GABA
    style GABA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (857)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.90
GABARAP	regulates	gene	0.90
LC3	activates	gene	0.80
MTOR	activates	gene	0.80
TFEB	activates	gene	0.80
LC3	regulates	gene	0.80
MTOR	regulates	gene	0.80
TFEB	regulates	gene	0.80
RNA	activates	gene	0.80
RNA	regulates	gene	0.80
ULK1	activates	gene	0.80
ULK1	regulates	gene	0.80
neurons	inhibits	cell_type	0.80
hippocampus	expressed_in	brain_region	0.80
cortex	expressed_in	brain_region	0.80
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
serotonin	associated_with	neurotransmitter	0.80
RB1	activates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
MTORC1	regulates	gene	0.70
PIK3C3	regulates	gene	0.70
RB1	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
RAS	activates	gene	0.70
MAP1LC3B	regulates	gene	0.70
RAS	regulates	gene	0.70
neurons	activates	cell_type	0.70
neurons	expressed_in	cell_type	0.70
stem cells	expressed_in	cell_type	0.70
GABAergic neurons	expressed_in	cell_type	0.70
GABRA1	inhibits	gene	0.70
AQP4	causes	gene	0.70
NEUROINFLAMMATION	inhibits	phenotype	0.70
ALZHEIMER'S DISEASE	causes	disease	0.70
TREM2	regulates	gene	0.70
EXCITOTOXICITY	protects_against	phenotype	0.70
EXCITOTOXICITY	inhibits	phenotype	0.70
COGNITIVE DECLINE	inhibits	phenotype	0.70
NEUROINFLAMMATION	treats	phenotype	0.70
RB1CC1	regulates	gene	0.70
LAMP2	regulates	gene	0.70
GABA-A receptor	inhibits	receptor	0.70
neurons	associated_with	cell_type	0.70
neurodegeneration	expressed_in	disease	0.70
serotonin receptor	expressed_in	receptor	0.70
NMDA receptor	expressed_in	receptor	0.70
Cancer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65

Incoming (466)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	0.98
rapamycin	targets	drug	0.90
MTOR	activates	gene	0.80
SLC6A13	associated_with	gene	0.80
ATG	activates	gene	0.80
ATG	regulates	gene	0.80
DNA	regulates	gene	0.70
BECN1	regulates	gene	0.70
AR	activates	gene	0.70
NEURONS	produces	cell_type	0.70
BACE1	produces	gene	0.70
BACE1	causes	gene	0.70
TAU	destabilizes	protein	0.70
BDNF	treats	gene	0.70
CASP3	associated_with	gene	0.66
PI3K	activates	gene	0.66
TAU	associated_with	protein	0.66
PARKINSON'S DISEASE	associated_with	disease	0.66
BDNF	associated_with	gene	0.66
AUTOPHAGY	regulates	phenotype	0.65
BDNF	targets	gene	0.65
AKT	causes	gene	0.65
DOPAMINE	inhibits	phenotype	0.65
RETINA	inhibits	brain_region	0.65
RILUZOLE	regulates	drug	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
OXIDATIVE STRESS	treats	phenotype	0.65
LC3	activates	protein	0.64
LC3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
WNT	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
CDH1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GABA

Understanding Entity Pages

Summary

Wiki Pages (21)

GABA (Gamma-Aminobutyric Acid) - Neurodegenerative Disease Biomarker

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Atypical Parkinsonism

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

PD Combination Therapy Matrix

Therapeutics

Neurons — Cell Type Hierarchy

PD Cure Roadmap

Astrocyte Reactivity Mechanism

CLCN10 — Chloride Voltage-Gated Channel 10

Circadian Rhythm in Neurodegeneration

cerebral-cortical-vasal-neurons

gabaergic-dysfunction

CNTN6 — Contactin 6

substantia-nigra