gene

SLC6A5

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SLC6A5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Solute Carrier Family 6 Member 5 (Glycine Transporter 1) gene

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🧬 Gene Info

Gene Symbol	SLC6A5
Aliases	Glycine Transporter 1
Chromosome	11p15.5
Protein Type	Receptor
Function	encodes a 12-transmembrane-domain protein of approximately 635 amino acids.
Primary Expression	astrocytes and endothelial cells of the blood-brain barrier
Amino Acids	635 aa
GeneCards	SLC6A5
Human Protein Atlas	SLC6A5
N-terminal intracellular domain	Contains regulatory motifs for protein kinase C (PKC) phosphorylation and interaction with scaffolding proteins.
Transmembrane core	Forms the substrate-binding pocket (S1 site) and the gated external vestibule. The transporter alternates between outward-facing and inward-facing conformations during the transport cycle.
Extracellular loops	Highly glycosylated, with N-linked glycosylation sites essential for proper folding and surface expression.
C-terminal intracellular tail	Contains a PDZ-binding motif for interaction with synaptic scaffolding proteins and determines subcellular localization.
Glycinergic tone	Steady-state glycine concentrations at glycine receptors
NMDA receptor modulation	Glycine is a co-agonist at NMDA-type glutamate receptors; GlyT1 indirectly regulates glutamatergic excitotoxicity through glycine availability
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC6A5 Gene

gene · 1653 words

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Pathway Diagram

graph TD
    SLC6A5["SLC6A5"]
    neurodegeneration["neurodegeneration"]
    SLC6A5 -->|"implicated_in"| neurodegeneration
    style SLC6A5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

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Debates (0)

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Related Research

Hypotheses and analyses mentioning SLC6A5 in their description or question text

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