Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SMARCA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SMARCA2 |
| Full Name | SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 |
| Aliases | BAF155 |
| Chromosome | 9p24.3 |
| Protein Type | Enzyme |
| Function | encodes an ATP-dependent chromatin remodeling enzyme that serves as the catalytic subunit of the SWI/SNF (BAF) complex. |
| Molecular Weight | 175 kDa |
| Amino Acids | 447 aa |
| Exons | 35 |
| UniProt ID | [P51531](https://www.uniprot.org/uniprot/P51531) |
| Ensembl ID | ENSG00000080503 |
| GeneCards | SMARCA2 |
| Human Protein Atlas | SMARCA2 |
| ncBAF (non-canonical BAF) | Contains BRM (but not BRG1) along with BRD9 and GLTSCR1. This complex is particularly important for neuron-specific gene regulation. |
| PBAF (polybromo BAF) | Requires BRG1 rather than BRM, but can incorporate BRM under certain conditions. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SMARCA2["SMARCA2"]
neurodegeneration["neurodegeneration"]
SMARCA2 -->|"implicated_in"| neurodegeneration
style SMARCA2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||