Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about snx1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SNX1 |
| Function | SNX1 (Sorting Nexin 1) is a key component of the membrane trafficking machinery with multiple essential cellular functions: |
| Molecular Weight | 53 kDa |
| Ensembl ID | ENSG00000128567 |
| GeneCards | SNX1 |
| Human Protein Atlas | SNX1 |
| VPS26/VPS29/VPS35 | The core cargo-selective complex that recognizes specific cargo proteins |
| SNX1/SNX2 | The membrane-deforming BAR domain-containing components that bend membranes into tubules or vesicles |
| Cargo Recognition | SNX1 can bind to ubiquitinated cargo destined for autophagic degradation |
| Membrane Bending | The BAR domain of SNX1 induces membrane curvature, facilitating the formation of transport carriers that retrieve cargo from endosomes |
| Sorting Decisions | SNX1 helps distinguish between proteins destined for degradation in lysosomes and those destined for recycling to the TGN or plasma membrane |
| Competition with degradation | By facilitating retrieval, SNX1 competes with the degradation pathway, ensuring proper protein homeostasis |
| Autophagosome Formation | SNX1 contributes to the recruitment of autophagy machinery to nascent autophagosomes |
| Maturation | SNX1 plays a role in autophagosome-endosome/lysosome fusion |
| Selective Autophagy Receptors | SNX1 interacts with autophagic cargo receptors to facilitate the recognition and engulfment of specific cellular components |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["snx1 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:SNX1 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:SNX1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning snx1 in their description or question text
No additional research found