| Gene Symbol | SNX1 |
| Function | SNX1 (Sorting Nexin 1) is a key component of the membrane trafficking machinery with multiple essential cellular functions: |
| Molecular Weight | 53 kDa |
| Ensembl ID | ENSG00000128567 |
| GeneCards | SNX1 |
| Human Protein Atlas | SNX1 |
| VPS26/VPS29/VPS35 | The core cargo-selective complex that recognizes specific cargo proteins |
| SNX1/SNX2 | The membrane-deforming BAR domain-containing components that bend membranes into tubules or vesicles |
| Cargo Recognition | SNX1 can bind to ubiquitinated cargo destined for autophagic degradation |
| Membrane Bending | The BAR domain of SNX1 induces membrane curvature, facilitating the formation of transport carriers that retrieve cargo from endosomes |
| Sorting Decisions | SNX1 helps distinguish between proteins destined for degradation in lysosomes and those destined for recycling to the TGN or plasma membrane |
| Competition with degradation | By facilitating retrieval, SNX1 competes with the degradation pathway, ensuring proper protein homeostasis |
| Autophagosome Formation | SNX1 contributes to the recruitment of autophagy machinery to nascent autophagosomes |
| Maturation | SNX1 plays a role in autophagosome-endosome/lysosome fusion |
| Selective Autophagy Receptors | SNX1 interacts with autophagic cargo receptors to facilitate the recognition and engulfment of specific cellular components |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |