Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| VASOPRESSIN | expressed_in | protein | 0.68 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-28 | 7 hypotheses Top: 0.662
neurodegeneration | 2026-04-28 | 3 hypotheses Top: 0.604
neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.604
neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.604
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Epigenetic clocks association with brain aging patterns in older women | exploratory | cognitive impairment and demen | 0.900 | 0.00 | human patients | proposed | N/A |
| iPSC-derived endothelial cell iron uptake with RLS CSF exposure | exploratory | restless legs syndrome | 0.900 | 0.00 | iPSC-derived human endothelial | proposed | N/A |
| s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
| s:** - Compare uptake with/without magnetic particles using tight junc | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $120,000 |
| AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| AAV Serotype Comparison for LRRK2 Knockdown in PD | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446] | Sehlin D, Hultqvist G, Michno W, Aguilar | J Prev Alzheimers Dis | 2025 | 1 |
| Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116] | Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z | Exp Neurol | 2023 | 1 |
| On Iron Metabolism and Its Regulation. [PMID:33925597] | Vogt AS, Arsiwala T, Mohsen M, Vogel M, | Int J Mol Sci | 2021 | 1 |
| Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546] | Feng H, Schorpp K, Jin J, Yozwiak CE, Ho | Cell Rep | 2020 | 1 |
| Transferrin and transferrin receptors update. [PMID:29969719] | Kawabata H | Free Radic Biol Med | 2019 | 1 |
| Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877] | Lu Y, Zhang Y, Niu C | Comp Biochem Physiol A Mol Int | 2026 | 0 |
| Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via [PMID:41666660] | Zhu D, Lu Y, Jamil S, Ashfaq H, Al-Emam | J Trace Elem Med Biol | 2026 | 0 |
| Role of iron and TfR1 in the application of high‑dose ascorbate against pancreat [PMID:41789665] | Piotrowsky A, Leischner C, Schmieder H, | Oncol Rep | 2026 | 0 |
| Yangxin granules exert cardioprotective effects against acute myocardial infarct [PMID:41868900] | Huo G, Zhou Y, Wu Z, Sun S, Zhu G, Cheng | American journal of translatio | 2026 | 0 |
| Conformational dynamics study of TfR1 upon transferrin binding via NMA and MD si [PMID:41921418] | Zemmouche M, Falque G, Cadet F, Gardebie | Journal of molecular graphics | 2026 | 0 |
| [Effects of acupuncture on ferroptosis and ferritinophagy in cerebral ischemia-r [PMID:41839581] | Wang YF, Dong YS | Zhen ci yan jiu = Acupuncture | 2026 | 0 |
| The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibit [PMID:41854751] | Nan K, Zhang L, Zhao Y, Yin S, Peng Y, H | Apoptosis : an international j | 2026 | 0 |
| The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis: A [PMID:41833023] | Osmanlioglu Dag SR, Tatli Cankaya II, Oz | Anti-cancer agents in medicina | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Raccoon eyes [PMID:35789012] | Ning Junjie | Journal of Paediatrics and Chi | 2023 | 0 |
| The Trend of Immunotherapy Combined with Nanomedicine. [PMID:34789123] | Shigao Huang; Qi Zhao | Current medicinal chemistry | 2022 | 0 |
| Test-retest reliability for performance-based outcome measures among individuals [PMID:35123456] | ["Sions J", "Donohoe M", "Beisheim-Ryan | BMC musculoskeletal disorders | 2022 | 0 |
| Interfacial Imide Polymerization of Functionalized Filled Microcapsule Templates [PMID:36234567] | ["Wei Z", "Ma X", "Wang P", "Pan J"] | Nanomaterials (Basel, Switzerl | 2022 | 0 |
| The impact of COVID-19 and non-pharmaceutical interventions on energy returns wo [PMID:36567890] | ["Saif-Alyousfi A", "Saha A"] | Sustainable cities and society | 2021 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.76 · 2026-04-28
closed · Rounds: 4 · Score: 0.64 · 2026-04-28
closed · Rounds: 4 · Score: 0.64 · 2026-04-28
closed · Rounds: 4 · Score: 0.64 · 2026-04-28
Hypotheses and analyses mentioning SON in their description or question text
Score: 0.720 · neurodegeneration · 2026-05-01
GBA1 mutations represent the strongest genetic risk factor for PD (OR 5-20x), and GCase dysfunction creates a druggable
Score: 0.719 · neurodegeneration · 2026-04-02
## Mechanistic Overview Magnetosonic-Triggered Transferrin Receptor Clustering starts from the claim that modulating TFR
Score: 0.710 · neurodegeneration · 2026-05-01
LRRK2 G2019S mutations cause autosomal dominant PD through hyperactivation that impairs vesicular trafficking via Rab GT
Score: 0.670 · neurodegeneration · 2026-04-29
Sporadic Parkinson's disease may involve impaired mitochondrial quality control, and NAD augmentation or other mitophagy
Score: 0.648 · neurodegeneration · 2026-04-02
## Mechanistic Overview HCN1-Mediated Resonance Frequency Stabilization Therapy starts from the claim that modulating HC
Score: 0.630 · neurodegeneration · 2026-04-30
Sporadic PD may include impaired mitochondrial quality control, reduced mitophagy flux, and dopaminergic vulnerability o
Score: 0.620 · neurodegeneration · 2026-04-21
## **Molecular Mechanism and Rationale** SUV39H1 (Suppressor of Variegation 3-9 Homolog 1), also known as KMT1A (lysine
Score: 0.610 · neuroinflammation · 2026-04-22
## Mechanistic Overview Age-Accelerated miR-155 Upregulation Primes Nigral Microglia for Parkinson's Disease Pathology s
Score: 0.604 · neurodegeneration · 2026-04-28
The debate supports carrying forward whether debate-structured causal reasoning improves calibration over direct LLM bas
Score: 0.595 · neurodegeneration · 2026-04-26
Misfolded α-synuclein aggregates are transmitted via exosomes from donor to recipient neurons, templating endogenous aSy