protein

SPECTRINALPHA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPECTRINALPHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	SPECTRINALPHA
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	various tissues including the brain and plays roles in neuronal function and disease mechanisms
Molecular Weight	284 kDa
GeneCards	SPECTRINALPHA
Human Protein Atlas	SPECTRINALPHA
SPTAN1 gene	Encodes the non-erythrocytic spectrin alpha chain
Spectrin beta protein	Forms heterodimers with spectrin alpha
Ankyrin	Major binding partner organizing spectrin complexes
Calpain proteases	Mediate spectrin alpha proteolysis in neurodegeneration
Axon initial segment	Critical neuronal compartment requiring spectrin alpha
Alpha-synuclein	Interacts pathologically with spectrin in Parkinson's disease
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Spectrin Alpha Protein

protein · 651 words

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Pathway Diagram

graph TD
    SPECTRINALPHA["SPECTRINALPHA"]
    neurodegeneration["neurodegeneration"]
    SPECTRINALPHA -->|"implicated_in"| neurodegeneration
    style SPECTRINALPHA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found