gene

SPG26

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SPG26: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

SPG26 (BAAT) gene encoding bile acid CoA:amino acid N-acyltransferase, linked to hereditary spastic paraplegia and neurodegeneration

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🧬 Gene Info

Gene Symbol	SPG26
Full Name	BAAT (Bile Acid CoA: Amino Acid N-Acyltransferase)
Chromosome	12q21.31
Protein Type	Enzyme
Function	This enzymatic reaction occurs in the liver peroxisomes and requires
Primary Expression	multiple tissues with varying levels:
Amino Acids	524 aa
UniProt ID	[Q8N6K6](https://www.uniprot.org/uniprotkb/Q8N6K6/entry)
GeneCards	SPG26
Human Protein Atlas	SPG26
Substrate	Bile acid-CoA (generated by BAAT or ACBD2)
Amino acid donor	Glycine or taurine
Coenzyme A	Released as byproduct
Location	Peroxisomes, endoplasmic reticulum
Liver	Highest expression - primary site of bile acid conjugation
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SPG26 Gene - Bile Acid CoA: Amino Acid N-Acyltransferase

gene · 1476 words

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Pathway Diagram

graph TD
    SPG26["SPG26"]
    neurodegeneration["neurodegeneration"]
    SPG26 -->|"implicated_in"| neurodegeneration
    style SPG26 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SPG26 in their description or question text

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