Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SPG35: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SPG35 |
| Full Name | FA2H (Fatty Acid 2-Hydroxylase) |
| Chromosome | 16q23.3 |
| Function | is a member of the fatty acid hydroxylase family and plays a vital role in maintaining myelin integrity in the central nervous system (CNS) [@myelin_lipids_2011]. |
| Subcellular Localization | s and enzymatic activities, which could explain the tissue-specific phenotype of FA2H-related disorders |
| Molecular Weight | 44 kDa |
| Amino Acids | 383 aa |
| Exons | 13 |
| UniProt ID | [Q8IWA4](https://www.uniprot.org/uniprotkb/Q8IWA4/entry) |
| GeneCards | SPG35 |
| Human Protein Atlas | SPG35 |
| Isoform 1 (canonical) | Full-length 383 amino acids, predominantly expressed in brain |
| Isoform 2 | Lacks exon 6, expressed in peripheral tissues |
| Isoform 3 | Alternative start site, truncated variant |
| Substrate specificity | Prefers C24 and C26 fatty acids |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SPG35["SPG35"]
neurodegeneration["neurodegeneration"]
SPG35 -->|"implicated_in"| neurodegeneration
style SPG35 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SPG35 in their description or question text
No additional research found