| Gene Symbol | SPG35 |
| Full Name | FA2H (Fatty Acid 2-Hydroxylase) |
| Chromosome | 16q23.3 |
| Function | is a member of the fatty acid hydroxylase family and plays a vital role in maintaining myelin integrity in the central nervous system (CNS) [@myelin_lipids_2011]. |
| Subcellular Localization | s and enzymatic activities, which could explain the tissue-specific phenotype of FA2H-related disorders |
| Molecular Weight | 44 kDa |
| Amino Acids | 383 aa |
| Exons | 13 |
| UniProt ID | [Q8IWA4](https://www.uniprot.org/uniprotkb/Q8IWA4/entry) |
| GeneCards | SPG35 |
| Human Protein Atlas | SPG35 |
| Isoform 1 (canonical) | Full-length 383 amino acids, predominantly expressed in brain |
| Isoform 2 | Lacks exon 6, expressed in peripheral tissues |
| Isoform 3 | Alternative start site, truncated variant |
| Substrate specificity | Prefers C24 and C26 fatty acids |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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