Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SST interneurons: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| gamma oscillations | regulates | process | 0.90 |
| Gamma oscillations | regulates | process | 0.90 |
| Entorhinal cortex layer II | associated_with | brain_region | 0.90 |
| hippocampal CA1 pyramidal neurons | inhibits | cell_type | 0.90 |
| gamma oscillation dynamics | regulates | process | 0.90 |
| gamma rhythm disruption | causes | phenotype | 0.70 |
| perforant path input | regulates | pathway | 0.70 |
| PV+ interneurons | inhibits | cell_type | 0.70 |
| gamma oscillations | modulates | process | 0.70 |
| Alzheimer's disease | vulnerable_in | disease | 0.70 |
| EC layer II | modulates | brain_region | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| amyloid-β oligomers | causes (specifically disrupt somatostatin-positive interne) | protein | 0.82 |
| C1Q | modulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plant-based dietary patterns and Alzheimer's disease risk in multiethn | clinical | Alzheimer's disease and relate | 0.950 | 0.00 | human patients | proposed | N/A |
| tFUS Targeting EC-II SST Interneurons Restores Hippocampal-Prefrontal | in_vivo | Alzheimer's disease | 0.744 | 0.48 | hAPP-J20 mice (n=10/group x 3 | abandoned | $110,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.65 · 2026-04-27
closed · Rounds: 4 · Score: 0.71 · 2026-04-27
closed · Rounds: 4 · Score: 0.87 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.54 · 2026-04-27
closed · Rounds: 4 · Score: 0.19 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-27
Hypotheses and analyses mentioning SST interneurons in their description or question text
Score: 0.748 · alzheimers · 2026-04-05
## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma gating and bloc
Score: 0.403 · alzheimers · 2026-04-26
Somatostatin-positive interneurons in entorhinal cortex layer II serve dual roles as gamma frequency gatekeepers and mic
Score: 0.380 · molecular-neurobiology · 2026-04-26
This hypothesis proposes that theta-gamma cross-frequency coupling (TGC) regulates lncRNA-9969 function through phase-de