entity

SST_interneurons

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SST_interneurons: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

9Hypotheses

2Analyses

3Outgoing

2Incoming

2Experiments

19Debates

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Wiki Pages (2)

Knowledge base pages for this entity

Validated Hypothesis: Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal gamma oscillations via upstream perforant path gating in Alzheimer's disease

hypothesis · 5341 words

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Validated Hypothesis: Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal-prefrontal synchrony in early AD

hypothesis · 4083 words

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Outgoing (3)

Target	Relation	Type	Str
theta_oscillations	regulates	phenotype	0.90
microglial inflammation	associated_with	phenotype	0.70
theta_oscillations	generates	physiological_process	0.50

Incoming (2)

Source	Relation	Type	Str
AMYLOID BETA OLIGOMERS	inhibits	protein	0.90
SST	expressed_in	gene	0.50

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.968	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.955	alzheimers	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.827	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II SST interneurons to block t	0.752	alzheimers	Circuit-level neural dynamics in neurode

Closed-loop focused ultrasound targeting EC-II SST interneur	0.748	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting motor	0.633	als	-
Closed-loop tFUS targeting of EC-II SST interneurons to prev	0.403	alzheimers	Circuit-level neural dynamics in neurode
Theta-Gamma Cross-Frequency Coupling Modulates lncRNA-9969 P	0.380	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp

Mentioning Analyses (2)

Scientific analyses that reference this entity

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

Alzheimer's disease | 2026-04-28 | 7 hypotheses Top: 0.670

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A
tFUS Targeting EC-II SST Interneurons Restores Hippocampal-Prefrontal	in_vivo	Alzheimer's disease	0.744	0.48	hAPP-J20 mice (n=10/group x 3	abandoned	$110,000

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024
Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890]	Burillo J, Marqués P, Jiménez B, Gonzále	Cells	2021
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169]	["Oakley, Holly", "Cole, Sarah L", "Loga	The Journal of neuroscience :	2006
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773]	["Hardy, John", "Selkoe, Dennis J"]	Science (New York, N.Y.)	2002