gene

SST

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

485Connections
15Hypotheses
4Analyses
50Outgoing
50Incoming

Summary

SST is a gene implicated in neurodegeneration research. Key relationships include: inhibits, therapeutic target, implicated in. Associated with Alzheimer's disease, Depression, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSST
Chromosome3q28
Protein TypeLigand
Target ClassLigand
FunctionThe SST gene encodes preprosomatostatin, which is processed to somatostatin-14 (the major form in the brain) and somatostatin-28 (predominant in the gut).
Mechanism of ActionSomatostatin is a peptide neurotransmitter that modulates neuronal signaling by inhibiting hormone release and neuronal excitability, with emerging evidence suggesting its potential neuroprotective role in neurodegenerative processes through regulation of inflammatory responses and synaptic plasticity. In neurodegeneration contexts, SST receptors may serve as modulators of neuroinflammatory cascades and potentially mitigate progressive neuronal damage through receptor-mediated signaling mechanisms.
DruggabilityLow (0.41)
Clinical StageApproved
Amino Acids14 aa
PathwaysAmyloid, affective empathy, gamma_oscillation, neuropeptide signaling, sleep-dependent growth hormone
UniProt IDP61278
Ensembl IDENSG00000136744
GeneCardsSST
Human Protein AtlasSST
Associated DiseasesALS, ALZHEIMER, AUTISM, Alzheimer's disease
Known Drugs/CompoundsOctreotide, Lanreotide
InteractionsMMP3, MMP9, NTS, NPY, ARNT2, KCNH7
SciDEX TargetView Target Profile (8 clinical trials)
SciDEX HypothesesClosed-loop tACS targeting EC-II SST interneurons
Closed-loop focused ultrasound targeting EC-II SST
Gamma entrainment therapy to restore hippocampal-c (+9 more)
KG Connections483 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: SST — AlphaFold P61278 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

SST Gene

gene · 1093 words

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

mechanism · 6138 words

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

therapeutic · 5600 words

Neurons — Cell Type Hierarchy

cell · 5551 words

Growth Factor Therapies

therapeutic · 4974 words

Pathway Diagram

graph TD
    SST["<b>SST</b>"]
    Alzheimer_s_disease{"Alzheimer's disease"}
    SST -->|"therapeutic target"| Alzheimer_s_disease
    gamma_oscillation(["gamma_oscillation"])
    SST -->|"regulates"| gamma_oscillation
    Ms{"Ms"}
    SST -->|"inhibits"| Ms
    Depression{"Depression"}
    SST -->|"inhibits"| Depression
    MMP3["MMP3"]
    SST -->|"inhibits"| MMP3
    Synaptic_Plasticity(["Synaptic Plasticity"])
    SST -->|"inhibits"| Synaptic_Plasticity
    Long_Term_Potentiation(["Long-Term Potentiation"])
    SST -->|"inhibits"| Long_Term_Potentiation
    MMP9["MMP9"]
    SST -->|"inhibits"| MMP9
    SST -->|"implicated in"| Alzheimer_s_disease
    neurodegeneration["neurodegeneration"]
    SST -->|"implicated in"| neurodegeneration
    h_bdbd2120["h-bdbd2120"]
    h_bdbd2120 -->|"therapeutic target"| SST
    h_bdbd2120 -->|"targets"| SST
    MMP9 -->|"inhibits"| SST
    style SST fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (307)

TargetRelationTypeStr
interneuronsregulatescell_type0.90
cortexexpressed_inbrain_region0.90
neuronsregulatescell_type0.90
neuronsexpressed_incell_type0.90
Tau Pathologyassociated_withbiomarker0.85

Incoming (178)

SourceRelationTypeStr
PVALBco_mentioned_withgene0.90
h-bdbd2120targets_genehypothesis0.90
h-f8316acftargets_genehypothesis0.90
h-var-e47f17ca3btargets_genehypothesis0.90
h-var-d749cd28cbtargets_genehypothesis0.90

Targeting Hypotheses (15)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Closed-loop tACS targeting EC-II SST interneurons to block t 0.697 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur 0.697 Alzheimer's disease Circuit-level neural dynamics in neurode
Gamma entrainment therapy to restore hippocampal-cortical sy 0.681 Alzheimer's disease Circuit-level neural dynamics in neurode
Beta-frequency entrainment therapy targeting PV interneuron- 0.669 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop transcranial alternating current stimulation to 0.639 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II 0.633 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in 0.625 Alzheimer's disease Circuit-level neural dynamics in neurode
Alpha-gamma cross-frequency coupling enhancement to restore 0.621 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo 0.614 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II 0.612 Alzheimer's disease Circuit-level neural dynamics in neurode
TREM2-ASM Crosstalk in Microglial Lysosomal Senescence 0.612 neurodegeneration Gene expression changes in aging mouse b
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener 0.607 neurodegeneration Gene expression changes in aging mouse b
Optogenetic restoration of hippocampal gamma oscillations vi 0.554 Alzheimer's disease Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe 0.538 Alzheimer's disease Circuit-level neural dynamics in neurode
Cardiovascular-Neuroinflammation Crosstalk Interruption 0.437 Alzheimer's disease Neuroinflammation and microglial priming

Mentioning Analyses (4)

Scientific analyses that reference this entity

Are interneuron oscillation deficits compensatory responses or primary pathologi

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.497

What specific astrocyte-derived factors can 'erase' pathological microglial memo

neuroinflammation | 2026-04-08 | 0 hypotheses

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 49 hypotheses Top: 0.709

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

neurodegeneration | 2026-04-01 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614] Han QQ, Shen SY, Liang LF, Chen XR, Yu J Brain Behav Immun 2024 1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] Zhang T, Xu D, Trefts E, Lv M, Inuzuka H Science 2023 1
Anatomical and neurochemical profiles of somatostatin-positive neurons in the mo [PMID:41796787] Tomioka R, Kobayashi K, Song WJ Neuroscience 2026 0
Subtype-Specific Roles of Anterior Cingulate Cortex Neurons in Pain-Induced Soci [PMID:41799202] Wan X, Yan Z, Zhang Z, Liu X, Yang D, Zh Theranostics 2026 0
A comparative analysis of pig-to-rhesus corneal xenotransplantation with various [PMID:41928466] Lee SH, Yoon CH, Choi HJ, Lee HJ, Kang H Korean J Ophthalmol 2026 0
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987] Vadalà A, Benelli C, Suraci F, Carta B, Arch Orthop Trauma Surg 2026 0
Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestat [PMID:41779871] Zhu H, Luo S, Liu C, Cheng Y, Ren Z, Mo Science translational medicine 2026 0
Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: [PMID:41854733] Liu K, Zhang XY, Wang YT, Wang R, Jin RH Molecular neurobiology 2026 0
Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138] Singer Y, Yitzhaky A, Hertzberg L Alpha psychiatry 2026 0
Paracrine inhibition via G protein inwardly rectifying potassium channels regula [PMID:41824458] Panzer JK, Lang AL, Levi NJ, Garcia PA, Cell reports 2026 0
Duloxetine Improves Early Clinical Outcomes Including Range of Motion, Functiona [PMID:41934361] Han SC, Han J, Min YK, Han JW, Jeong HJ Am J Sports Med 2026 0
Modeling and simulation of conducting airways during continuous high-frequency o [PMID:41941967] Huang X, Francis I, Gu Y, Saha SC Respir Physiol Neurobiol 2026 0
Potential antidepressant properties of aminophylline in male mice exposed to chr [PMID:41945313] Samante FI, Galangue CG, Avelino DC, Bel Pharmacol Rep 2026 0
Robot-assisted immediate implant placement with the socket shield technique in t [PMID:41963213] Wu J, Lin B, Yang S, Xu S, Li S J Prosthet Dent 2026 0
GADD45G operates as a pathological sensor orchestrating reactive gliosis and neu [PMID:40409253] Shen T, Tai W, Jiang D, Ma S, Zhong X, Z Neuron 2025 0
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheime [PMID:41035073] Castanho I, Naderi Yeganeh P, Boix CA, M Molecular neurodegeneration 2025 0
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974] Dai L, Wang J, Meng L, Zhang X, Xiao T, PLoS biology 2025 0
Molecular hallmarks of excitatory and inhibitory neuronal resilience and resista [PMID:39868232] Castanho I, Yeganeh PN, Boix CA, Morgan bioRxiv : the preprint server 2025 0
From stress to Alzheimer's: A circuit-based framework for prefrontal cognitive d [PMID:41115499] Yi JH Neuroscience letters 2025 0
Hippocampal Interneurons Shape Spatial Coding Alterations in Neurological Disord [PMID:40392508] Ikebara JM, Jorge RS, Marinho LSR, Higa Molecular neurobiology 2025 0